C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: smoothened homolog (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000002952 smo 7955 + 4:14036631-14045329 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000005985 smo-001 14036631-14045329 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000005985
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000005985 1.395±0.23 2.612±0.74 0.690±0.14 0.163±0.00 0.571±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00024K CIL_00024K_0001 CGP 4:14022752-14045329

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001570 IMP vasculogenesis
GO:0001649 IBA osteoblast differentiation
GO:0001755 IBA neural crest cell migration
GO:0001839 IMP neural plate morphogenesis
GO:0001947 IMP heart looping
GO:0002052 IBA positive regulation of neuroblast proliferation
GO:0002053 IBA positive regulation of mesenchymal cell proliferation
GO:0003007 IBA heart morphogenesis
GO:0003231 IMP cardiac ventricle development
GO:0004871 IEA signal transducer activity
GO:0004888 IEA transmembrane signaling receptor activity
GO:0004930 IEA G-protein coupled receptor activity
GO:0005515 IEA protein binding
GO:0005737 IBA cytoplasm
GO:0005886 IBA plasma membrane
GO:0005929 IBA cilium
GO:0007165 IEA signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007224 IEA smoothened signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0007283 IBA spermatogenesis
GO:0007368 IBA determination of left/right symmetry
GO:0007399 IMP nervous system development
GO:0007411 IMP axon guidance
GO:0007417 IMP central nervous system development
GO:0007517 IMP muscle organ development
GO:0008406 IBA gonad development
GO:0009880 IMP embryonic pattern specification
GO:0009952 IMP anterior/posterior pattern specification
GO:0010002 IMP cardioblast differentiation
GO:0014003 IMP oligodendrocyte development
GO:0014033 IMP neural crest cell differentiation
GO:0016020 IEA membrane
GO:0016021 IEA integral to membrane
GO:0017147 IBA Wnt-protein binding
GO:0021508 IGI floor plate formation
GO:0021520 IMP spinal cord motor neuron cell fate specification
GO:0021523 IMP somatic motor neuron differentiation
GO:0021536 IGI diencephalon development
GO:0021537 IMP telencephalon development
GO:0021561 IBA facial nerve development
GO:0021587 IMP cerebellum morphogenesis
GO:0021696 IBA cerebellar cortex morphogenesis
GO:0021782 IMP glial cell development
GO:0021798 IMP forebrain dorsal/ventral pattern formation
GO:0021904 IBA dorsal/ventral neural tube patterning
GO:0021910 IBA smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938 IBA smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953 IBA central nervous system neuron differentiation
GO:0021984 IMP adenohypophysis development
GO:0030165 IBA PDZ domain binding
GO:0030182 IMP neuron differentiation
GO:0030239 IMP myofibril assembly
GO:0030900 IMP forebrain development
GO:0030902 IMP hindbrain development
GO:0031016 IMP pancreas development
GO:0031017 IMP exocrine pancreas development
GO:0031018 IMP endocrine pancreas development
GO:0031076 IDA embryonic camera-type eye development
GO:0031102 IBA neuron projection regeneration
GO:0031290 IMP retinal ganglion cell axon guidance
GO:0032474 IMP otolith morphogenesis
GO:0035143 IMP caudal fin morphogenesis
GO:0035270 IMP endocrine system development
GO:0035479 IMP angioblast cell migration from lateral mesoderm to midline
GO:0035912 IMP dorsal aorta morphogenesis
GO:0042472 IMP inner ear morphogenesis
GO:0042475 IBA odontogenesis of dentin-containing tooth
GO:0042693 IMP muscle cell fate commitment
GO:0042813 IBA Wnt-activated receptor activity
GO:0043025 IBA neuronal cell body
GO:0043066 IBA negative regulation of apoptotic process
GO:0045880 IBA positive regulation of smoothened signaling pathway
GO:0048557 IMP embryonic digestive tract morphogenesis
GO:0048663 IMP neuron fate commitment
GO:0048702 IMP embryonic neurocranium morphogenesis
GO:0048703 IMP embryonic viscerocranium morphogenesis
GO:0048741 IMP skeletal muscle fiber development
GO:0048745 IMP smooth muscle tissue development
GO:0048752 IMP semicircular canal morphogenesis
GO:0048794 IMP swim bladder development
GO:0048795 IMP swim bladder morphogenesis
GO:0048839 IMP inner ear development
GO:0048846 IBA axon extension involved in axon guidance
GO:0050679 IBA positive regulation of epithelial cell proliferation
GO:0051216 IMP cartilage development
GO:0055002 IMP striated muscle cell development
GO:0060041 IMP retina development in camera-type eye
GO:0060070 IBA canonical Wnt receptor signaling pathway
GO:0060830 IMP ciliary receptor clustering involved in smoothened signaling pathway
GO:0060844 IMP arterial endothelial cell fate commitment
GO:0060896 IMP neural plate pattern specification
GO:0060956 IMP endocardial cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000128602 SMO smoothened, frizzled class receptor protein_coding Homo_sapiens
ENSMUSG00000001761 Smo smoothened homolog (Drosophila) protein_coding Mus_musculus

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