C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: smoothened homolog (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000001761 Smo 10090 + 6:29735694-29761365 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000001812 Smo-001 29735694-29761365 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000001812
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000001812 22.591±7.83 30.620±3.51 17.160±1.67 8.818±6.58 17.637±2.96 15.367±0.83 3.060±0.89 23.818±2.03 4.261±1.07 16.978±0.79 1.022±0.28 40.635±11.23 4.100±2.57 1.544±0.58

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00024K CIL_00024K_0003 CGP 6:29694222-29761365
CIL_0001YH CIL_0001YH_0002 CGP 6:29735694-29912310

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001503 IMP ossification
GO:0001570 IMP vasculogenesis
GO:0001649 IMP osteoblast differentiation
GO:0001701 IMP in utero embryonic development
GO:0001708 IMP cell fate specification
GO:0001755 IGI neural crest cell migration
GO:0001947 IMP heart looping
GO:0002052 IGI positive regulation of neuroblast proliferation
GO:0002053 IMP positive regulation of mesenchymal cell proliferation
GO:0003007 IGI heart morphogenesis
GO:0003140 IMP determination of left/right asymmetry in lateral mesoderm
GO:0003323 IMP type B pancreatic cell development
GO:0004930 IEA G-protein coupled receptor activity
GO:0005113 IEA patched binding
GO:0005737 IBA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005886 ISS plasma membrane
GO:0005901 IEA caveola
GO:0005929 IDA cilium
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007224 IMP smoothened signaling pathway
GO:0007228 IMP positive regulation of hh target transcription factor activity
GO:0007283 IBA spermatogenesis
GO:0007368 IMP determination of left/right symmetry
GO:0007371 IMP ventral midline determination
GO:0007389 IMP pattern specification process
GO:0007417 IGI central nervous system development
GO:0007494 IMP midgut development
GO:0008144 IDA drug binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008406 IBA gonad development
GO:0009952 IMP anterior/posterior pattern specification
GO:0009953 IMP dorsal/ventral pattern formation
GO:0010002 IBA cardioblast differentiation
GO:0010468 IGI regulation of gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IMP negative regulation of gene expression
GO:0016021 IEA integral component of membrane
GO:0017147 IBA Wnt-protein binding
GO:0021508 IBA floor plate formation
GO:0021561 IBA facial nerve development
GO:0021696 IMP cerebellar cortex morphogenesis
GO:0021794 IMP thalamus development
GO:0021904 IMP dorsal/ventral neural tube patterning
GO:0021910 IMP smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938 IMP smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953 IMP central nervous system neuron differentiation
GO:0021984 IBA adenohypophysis development
GO:0030165 IBA PDZ domain binding
GO:0030857 IMP negative regulation of epithelial cell differentiation
GO:0031017 IBA exocrine pancreas development
GO:0031069 IMP hair follicle morphogenesis
GO:0031076 IBA embryonic camera-type eye development
GO:0031102 IBA neuron projection regeneration
GO:0032474 IBA otolith morphogenesis
GO:0034504 IMP protein localization to nucleus
GO:0035264 IGI multicellular organism growth
GO:0042307 IGI positive regulation of protein import into nucleus
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0042693 IBA muscle cell fate commitment
GO:0042813 IBA Wnt-activated receptor activity
GO:0043025 IBA neuronal cell body
GO:0043066 IMP negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043392 IGI negative regulation of DNA binding
GO:0045880 IMP positive regulation of smoothened signaling pathway
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048468 IMP cell development
GO:0048557 IBA embryonic digestive tract morphogenesis
GO:0048565 IMP digestive tract development
GO:0048568 IGI embryonic organ development
GO:0048589 IMP developmental growth
GO:0048663 IBA neuron fate commitment
GO:0048702 IBA embryonic neurocranium morphogenesis
GO:0048703 IBA embryonic viscerocranium morphogenesis
GO:0048741 IMP skeletal muscle fiber development
GO:0048752 IBA semicircular canal morphogenesis
GO:0048846 IBA axon extension involved in axon guidance
GO:0048853 IMP forebrain morphogenesis
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050821 IDA protein stabilization
GO:0051451 IGI myoblast migration
GO:0051799 IMP negative regulation of hair follicle development
GO:0060070 IBA canonical Wnt signaling pathway
GO:0060170 IDA ciliary membrane
GO:0060248 ISS detection of cell density by contact stimulus involved in contact inhibition
GO:0060413 IGI atrial septum morphogenesis
GO:0060644 IMP mammary gland epithelial cell differentiation
GO:0060684 IMP epithelial-mesenchymal cell signaling
GO:0060830 IBA ciliary receptor clustering involved in smoothened signaling pathway
GO:0061053 IMP somite development
GO:0061113 IMP pancreas morphogenesis
GO:0070062 IEA extracellular vesicular exosome
GO:0071397 IEP cellular response to cholesterol
GO:0072001 IEA renal system development
GO:0072285 IMP mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0072372 IDA primary cilium
GO:0090190 IMP positive regulation of branching involved in ureteric bud morphogenesis
GO:2000036 IMP regulation of stem cell maintenance
GO:2000826 IMP regulation of heart morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002952 smo smoothened homolog (Drosophila) protein_coding Danio_rerio
ENSG00000128602 SMO smoothened, frizzled class receptor protein_coding Homo_sapiens

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