C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: smoothened, frizzled class receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128602 SMO 9606 + 7:129188872-129213545 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000249373 SMO-001 129188872-129213545 protein_coding
  ENST00000462420 SMO-003 129206150-129211128 nonsense_mediated_decay
  ENST00000475779 SMO-004 129210508-129212152 nonsense_mediated_decay
  ENST00000495998 SMO-002 129206285-129209281 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000249373ENST00000462420
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000249373 1.681±0.00 2.767±0.00 1.593±0.00 2.906±0.00 2.831±1.67 3.874±0.00 0.520±0.35 6.265±1.82 3.798±2.45 0.893±0.59 0.278±0.25 12.099±11.73 2.513±0.80 7.584±4.05
ENST00000462420 N/A N/A N/A 1.025±0.00 N/A N/A N/A N/A N/A 0.832±0.00 N/A N/A 3.963±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00024K CIL_00024K_0002 CGP 7:129144892-129213545
CIL_0001YH CIL_0001YH_0001 CGP 7:129188872-129430211

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001503 IEA ossification
GO:0001570 IBA vasculogenesis
GO:0001649 IBA osteoblast differentiation
GO:0001701 IEA in utero embryonic development
GO:0001708 IEA cell fate specification
GO:0001755 IBA neural crest cell migration
GO:0001947 ISS heart looping
GO:0002052 IBA positive regulation of neuroblast proliferation
GO:0002053 IBA positive regulation of mesenchymal cell proliferation
GO:0003007 IBA heart morphogenesis
GO:0003140 ISS determination of left/right asymmetry in lateral mesoderm
GO:0003323 IEA type B pancreatic cell development
GO:0004888 IEA transmembrane signaling receptor activity
GO:0004930 IEA G-protein coupled receptor activity
GO:0005113 IPI patched binding
GO:0005515 IPI:IEA protein binding
GO:0005737 IBA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005886 IBA plasma membrane
GO:0005901 IDA caveola
GO:0005929 IBA cilium
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007224 IEP smoothened signaling pathway
GO:0007228 ISS positive regulation of hh target transcription factor activity
GO:0007283 IBA spermatogenesis
GO:0007368 IBA determination of left/right symmetry
GO:0007371 ISS ventral midline determination
GO:0007389 IEA pattern specification process
GO:0007417 IEA central nervous system development
GO:0007494 ISS midgut development
GO:0008144 IDA drug binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008406 IBA gonad development
GO:0009952 IEA anterior/posterior pattern specification
GO:0009953 IEA dorsal/ventral pattern formation
GO:0010002 IBA cardioblast differentiation
GO:0010468 IEA regulation of gene expression
GO:0010628 ISS positive regulation of gene expression
GO:0010629 ISS negative regulation of gene expression
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0017147 IBA Wnt-protein binding
GO:0021508 IBA floor plate formation
GO:0021561 IBA facial nerve development
GO:0021696 IBA cerebellar cortex morphogenesis
GO:0021794 IEA thalamus development
GO:0021904 IBA dorsal/ventral neural tube patterning
GO:0021910 IBA smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938 IBA smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953 IBA central nervous system neuron differentiation
GO:0021984 IBA adenohypophysis development
GO:0030165 IBA PDZ domain binding
GO:0030857 IEA negative regulation of epithelial cell differentiation
GO:0031017 IBA exocrine pancreas development
GO:0031069 IEA hair follicle morphogenesis
GO:0031076 IBA embryonic camera-type eye development
GO:0031102 IBA neuron projection regeneration
GO:0032474 IBA otolith morphogenesis
GO:0034504 IEA protein localization to nucleus
GO:0035264 IEA multicellular organism growth
GO:0042307 IEA positive regulation of protein import into nucleus
GO:0042475 IBA odontogenesis of dentin-containing tooth
GO:0042693 IBA muscle cell fate commitment
GO:0042813 IBA Wnt-activated receptor activity
GO:0043025 IBA neuronal cell body
GO:0043066 IBA negative regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043392 ISS negative regulation of DNA binding
GO:0045880 IBA positive regulation of smoothened signaling pathway
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048468 IEA cell development
GO:0048557 IBA embryonic digestive tract morphogenesis
GO:0048565 IEA digestive tract development
GO:0048568 IEA embryonic organ development
GO:0048589 IEA developmental growth
GO:0048663 IBA neuron fate commitment
GO:0048702 IBA embryonic neurocranium morphogenesis
GO:0048703 IBA embryonic viscerocranium morphogenesis
GO:0048741 IEA skeletal muscle fiber development
GO:0048752 IBA semicircular canal morphogenesis
GO:0048846 IBA axon extension involved in axon guidance
GO:0048853 ISS forebrain morphogenesis
GO:0050679 IBA positive regulation of epithelial cell proliferation
GO:0050821 IEA protein stabilization
GO:0051451 IEA myoblast migration
GO:0051799 IEA negative regulation of hair follicle development
GO:0060070 IBA canonical Wnt signaling pathway
GO:0060170 IEA ciliary membrane
GO:0060248 IMP detection of cell density by contact stimulus involved in contact inhibition
GO:0060413 IEA atrial septum morphogenesis
GO:0060644 IEA mammary gland epithelial cell differentiation
GO:0060684 IEA epithelial-mesenchymal cell signaling
GO:0060830 IBA ciliary receptor clustering involved in smoothened signaling pathway
GO:0061053 ISS somite development
GO:0061113 IEA pancreas morphogenesis
GO:0070062 IDA extracellular vesicular exosome
GO:0071397 ISS cellular response to cholesterol
GO:0072001 IEP renal system development
GO:0072285 ISS mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0072372 TAS primary cilium
GO:0090190 ISS positive regulation of branching involved in ureteric bud morphogenesis
GO:2000036 IEA regulation of stem cell maintenance
GO:2000826 ISS regulation of heart morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002952 smo smoothened homolog (Drosophila) protein_coding Danio_rerio
ENSMUSG00000001761 Smo smoothened homolog (Drosophila) protein_coding Mus_musculus

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