C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) II beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSDARG00000034195 top2b 7955 - 19:19676650-19763184 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSDART00000029024 top2b-201 19676999-19763175 protein_coding
  ENSDART00000130695 top2b-001 19676650-19763184 protein_coding
  ENSDART00000151133 top2b-002 19733556-19763175 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000029024ENSDART00000130695
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000029024 21.057±6.97 1.970±0.00 2.354±0.00 0.161±0.00 0.671±0.00
ENSDART00000130695 15.917±5.49 6.400±4.03 3.790±2.95 1.058±0.00 2.252±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0000712 IBA resolution of meiotic recombination intermediates
GO:0000795 IBA synaptonemal complex
GO:0000819 IBA sister chromatid segregation
GO:0003677 IEA DNA binding
GO:0003682 IBA chromatin binding
GO:0003916 IEA DNA topoisomerase activity
GO:0003918 IEA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 IBA protein kinase C binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0006200 ISS ATP catabolic process
GO:0006259 IEA DNA metabolic process
GO:0006261 IBA DNA-dependent DNA replication
GO:0006265 IEA DNA topological change
GO:0006312 IBA mitotic recombination
GO:0007059 ISS chromosome segregation
GO:0007412 IMP axon target recognition
GO:0008094 ISS DNA-dependent ATPase activity
GO:0009330 ISS DNA topoisomerase complex (ATP-hydrolyzing)
GO:0010842 IMP retina layer formation
GO:0016853 IEA isomerase activity
GO:0030261 ISS chromosome condensation
GO:0031290 IMP retinal ganglion cell axon guidance
GO:0042826 IBA histone deacetylase binding
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0071778 IBA WINAC complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000077097 TOP2B topoisomerase (DNA) II beta 180kDa protein_coding Homo_sapiens
ENSMUSG00000017485 Top2b topoisomerase (DNA) II beta protein_coding Mus_musculus

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