C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: topoisomerase (DNA) II beta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSDART00000130695 top2b-001 ENSDARG00000034195 7955 - 19:19676650-19763184 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainHeartKidneyLiverMuscleENSDART00000130695
Transcript ID Brain Heart Kidney Liver Muscle
ENSDART00000130695 15.917±5.49 6.400±4.03 3.790±2.95 1.058±0.00 2.252±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0000712 IBA resolution of meiotic recombination intermediates
GO:0000795 IBA synaptonemal complex
GO:0000819 IBA sister chromatid segregation
GO:0003677 IEA DNA binding
GO:0003682 IBA chromatin binding
GO:0003916 IEA DNA topoisomerase activity
GO:0003918 IEA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 IBA protein kinase C binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0006200 ISS ATP catabolic process
GO:0006259 IEA DNA metabolic process
GO:0006261 IBA DNA-dependent DNA replication
GO:0006265 IEA DNA topological change
GO:0006312 IBA mitotic recombination
GO:0007059 ISS chromosome segregation
GO:0007412 IMP axon target recognition
GO:0008094 ISS DNA-dependent ATPase activity
GO:0009330 ISS DNA topoisomerase complex (ATP-hydrolyzing)
GO:0010842 IMP retina layer formation
GO:0016853 IEA isomerase activity
GO:0030261 ISS chromosome condensation
GO:0031290 IMP retinal ganglion cell axon guidance
GO:0042826 IBA histone deacetylase binding
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0071778 IBA WINAC complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000264331 TOP2B-201 protein_coding Homo_sapiens 0 1781
ENST00000424225 TOP2B-002 protein_coding Homo_sapiens 0 1781
ENST00000435706 TOP2B-001 protein_coding Homo_sapiens 0 1781
ENST00000491510 TOP2B-006 retained_intron Homo_sapiens 0 350

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