C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) II beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000017485 Top2b 10090 + 14:16365179-16430787 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000017629 Top2b-001 16365179-16430787 protein_coding
  ENSMUST00000159302 Top2b-004 16412083-16416709 nonsense_mediated_decay
  ENSMUST00000159987 Top2b-002 16389577-16393426 retained_intron
  ENSMUST00000160501 Top2b-003 16409908-16417030 protein_coding
  ENSMUST00000161693 Top2b-006 16413717-16425437 protein_coding
  ENSMUST00000163032 Top2b-005 16423288-16428505 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000017629ENSMUST00000160501
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000017629 5.858±1.36 7.688±4.53 16.792±0.70 42.445±13.09 9.394±3.77 3.629±1.16 5.145±0.59 4.140±0.90 9.129±6.71 10.578±1.90 4.852±0.86 9.567±8.83 11.908±3.06 1.913±1.26
ENSMUST00000160501 N/A N/A N/A 58.885±0.00 8.141±2.57 N/A 6.686±0.00 N/A N/A N/A N/A 91.959±0.00 61.902±5.22 15.993±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000712 IBA resolution of meiotic recombination intermediates
GO:0000792 IEA heterochromatin
GO:0000819 IBA sister chromatid segregation
GO:0001764 IMP neuron migration
GO:0003682 IEA chromatin binding
GO:0003918 ISS DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 IEA protein kinase C binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 IEA nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0006200 IEA ATP catabolic process
GO:0006265 ISS DNA topological change
GO:0006268 IBA DNA unwinding involved in DNA replication
GO:0006312 IBA mitotic recombination
GO:0007409 IMP axonogenesis
GO:0008022 IEA protein C-terminus binding
GO:0008301 IEA DNA binding, bending
GO:0009330 IBA DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019899 IEA enzyme binding
GO:0030900 IMP forebrain development
GO:0042826 IEA histone deacetylase binding
GO:0044774 IBA mitotic DNA integrity checkpoint
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034195 top2b topoisomerase (DNA) II beta protein_coding Danio_rerio
ENSG00000077097 TOP2B topoisomerase (DNA) II beta 180kDa protein_coding Homo_sapiens

Loading