C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) II beta 180kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000077097 TOP2B 9606 - 3:25597905-25664907 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264331 TOP2B-201 25597905-25664372 protein_coding
  ENST00000413971 TOP2B-005 25597984-25618849 nonsense_mediated_decay
  ENST00000424225 TOP2B-002 25615473-25664907 protein_coding
  ENST00000435706 TOP2B-001 25597986-25664499 protein_coding
  ENST00000470132 TOP2B-007 25624352-25625038 retained_intron
  ENST00000475717 TOP2B-008 25612571-25615941 processed_transcript
  ENST00000491510 TOP2B-006 25627057-25630155 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264331ENST00000413971ENST00000424225ENST00000435706
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264331 N/A 5.772±0.00 2.106±0.00 3.410±0.00 5.334±0.00 N/A N/A N/A 2.937±0.00 N/A N/A 2.981±0.00 2.617±0.00 N/A
ENST00000413971 9.522±0.00 20.469±0.00 N/A 21.162±0.00 16.725±0.00 22.833±0.00 N/A 16.787±0.00 7.657±0.00 16.476±0.00 4.069±2.36 17.836±6.15 10.820±1.86 20.415±0.00
ENST00000424225 N/A N/A N/A N/A N/A N/A 1.922±0.00 N/A N/A N/A 0.986±0.00 4.606±0.00 N/A N/A
ENST00000435706 10.034±0.00 4.317±0.00 N/A 22.118±0.00 8.788±0.00 12.389±0.00 9.090±7.79 7.894±3.83 4.985±1.59 8.733±0.00 9.849±0.00 2.711±0.00 3.973±0.51 8.759±4.08

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000712 IBA resolution of meiotic recombination intermediates
GO:0000792 IDA heterochromatin
GO:0000819 IBA sister chromatid segregation
GO:0001764 IEA neuron migration
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003918 IDA:IEA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 IPI protein kinase C binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA:IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006200 IEA ATP catabolic process
GO:0006265 IDA:IEA DNA topological change
GO:0006268 IBA DNA unwinding involved in DNA replication
GO:0006312 IBA mitotic recombination
GO:0007409 IEA axonogenesis
GO:0008022 IPI protein C-terminus binding
GO:0008301 IEA DNA binding, bending
GO:0009330 IBA DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019899 IPI enzyme binding
GO:0030900 IEA forebrain development
GO:0042826 IPI histone deacetylase binding
GO:0044774 IBA mitotic DNA integrity checkpoint
GO:0046872 IEA metal ion binding
GO:0046982 IPI protein heterodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034195 top2b topoisomerase (DNA) II beta protein_coding Danio_rerio
ENSMUSG00000017485 Top2b topoisomerase (DNA) II beta protein_coding Mus_musculus

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