C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CASP8 and FADD-like apoptosis regulator
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000003402 CFLAR 9606 + 2:201116104-201176687 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309955 CFLAR-001 201116104-201176687 protein_coding
  ENST00000340870 CFLAR-201 201133036-201160943 protein_coding
  ENST00000341222 CFLAR-003 201116167-201141598 protein_coding
  ENST00000341582 CFLAR-006 201116207-201164279 protein_coding
  ENST00000342795 CFLAR-007 201116239-201154576 protein_coding
  ENST00000395148 CFLAR-005 201116407-201139877 protein_coding
  ENST00000417748 CFLAR-018 201129329-201133102 protein_coding
  ENST00000423241 CFLAR-008 201118491-201164110 protein_coding
  ENST00000425030 CFLAR-017 201122477-201130053 protein_coding
  ENST00000433445 CFLAR-016 201117039-201130059 protein_coding
  ENST00000439154 CFLAR-009 201118664-201160455 nonsense_mediated_decay
  ENST00000440180 CFLAR-010 201129503-201141602 protein_coding
  ENST00000441224 CFLAR-015 201116837-201133134 protein_coding
  ENST00000443227 CFLAR-002 201116154-201164162 protein_coding
  ENST00000457277 CFLAR-011 201129866-201163559 protein_coding
  ENST00000460961 CFLAR-024 201133030-201136414 retained_intron
  ENST00000461422 CFLAR-020 201129977-201140661 retained_intron
  ENST00000461820 CFLAR-019 201129643-201136281 retained_intron
  ENST00000462763 CFLAR-023 201132953-201149835 protein_coding
  ENST00000470178 CFLAR-022 201132872-201141407 protein_coding
  ENST00000470664 CFLAR-026 201148951-201150355 retained_intron
  ENST00000474842 CFLAR-014 201140186-201163973 retained_intron
  ENST00000479953 CFLAR-012 201132984-201163157 protein_coding
  ENST00000490965 CFLAR-027 201118523-201119177 processed_transcript
  ENST00000494258 CFLAR-021 201132779-201140735 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309955ENST00000341222ENST00000341582ENST00000395148ENST00000423241ENST00000441224ENST00000457277
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309955 11.498±0.00 9.774±0.00 N/A 1.183±0.34 7.792±4.21 4.284±0.29 3.766±0.00 6.267±3.08 4.095±0.75 9.404±0.00 6.066±2.76 3.647±1.55 3.937±0.62 1.378±0.00
ENST00000341222 N/A N/A N/A N/A N/A N/A N/A N/A N/A 106.363±0.00 N/A N/A 23.830±0.00 N/A
ENST00000341582 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 28.344±0.00 N/A N/A N/A
ENST00000395148 N/A N/A 5.924±0.00 N/A 9.685±0.00 N/A N/A N/A N/A 18.323±0.00 N/A 8.504±0.00 N/A N/A
ENST00000423241 N/A N/A N/A N/A N/A 11.907±0.00 N/A N/A N/A N/A N/A N/A 11.492±1.49 N/A
ENST00000441224 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 70.202±0.00 34.875±0.00 N/A
ENST00000457277 N/A N/A N/A N/A N/A N/A 16.947±0.00 N/A N/A N/A 14.522±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IPI protease binding
GO:0004197 IEA cysteine-type endopeptidase activity
GO:0005123 IEA death receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006508 IEA proteolysis
GO:0006915 IMP:IEA apoptotic process
GO:0007519 ISS skeletal muscle tissue development
GO:0008047 IDA enzyme activator activity
GO:0008234 IEA cysteine-type peptidase activity
GO:0014732 ISS skeletal muscle atrophy
GO:0014842 ISS regulation of satellite cell proliferation
GO:0014866 ISS skeletal myofibril assembly
GO:0016032 IEA viral process
GO:0031264 IDA death-inducing signaling complex
GO:0031265 IEA CD95 death-inducing signaling complex
GO:0032403 IEA protein complex binding
GO:0035877 IBA death effector domain binding
GO:0042981 IEA regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043085 IDA positive regulation of catalytic activity
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043403 ISS skeletal muscle tissue regeneration
GO:0045121 IEA membrane raft
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0060544 IDA regulation of necroptotic process
GO:0097190 TAS apoptotic signaling pathway
GO:0097342 IDA ripoptosome
GO:1901740 ISS negative regulation of myoblast fusion
GO:1902042 IMP negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway
GO:2001239 TAS regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055966 cflara CASP8 and FADD-like apoptosis regulator a protein_coding Danio_rerio
ENSDARG00000074802 cflarb CASP8 and FADD-like apoptosis regulator b protein_coding Danio_rerio
ENSMUSG00000026031 Cflar CASP8 and FADD-like apoptosis regulator protein_coding Mus_musculus
ENSMUSG00000050533 Gm9845 predicted pseudogene 9845 protein_coding Mus_musculus

Loading