C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate dehydrogenase kinase, isozyme 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000004799 PDK4 9606 - 7:95583499-95596491 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000005178 PDK4-001 95583499-95596491 protein_coding
  ENST00000468445 PDK4-005 95586680-95587545 retained_intron
  ENST00000473301 PDK4-003 95594771-95596460 retained_intron
  ENST00000473796 PDK4-002 95584375-95592760 retained_intron
  ENST00000498190 PDK4-004 95587484-95589717 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000005178ENST00000473796
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000005178 463.153±0.00 33.174±0.00 6.978±0.00 10.885±5.42 47.127±20.76 124.324±116.22 290.842±277.06 75.467±35.06 19.484±1.47 21.167±4.86 624.585±436.87 12.754±11.18 23.913±12.09 15.416±13.49
ENST00000473796 N/A N/A 2.373±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008H4 CIL_0008H4_0001 VISTA 7:95307310-95911146
CIL_0006QC CIL_0006QC_0002 CGP 7:95478444-95596491
CIL_00053G CIL_00053G_0001 CGP 7:95583499-96110071

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004740 ISS pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 IDA ATP binding
GO:0005739 TAS mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0005759 TAS mitochondrial matrix
GO:0006006 IEA glucose metabolic process
GO:0006090 TAS pyruvate metabolic process
GO:0006468 IEA protein phosphorylation
GO:0006885 ISS regulation of pH
GO:0008286 IMP insulin receptor signaling pathway
GO:0009267 IDA cellular response to starvation
GO:0010510 IMP regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565 ISS regulation of cellular ketone metabolic process
GO:0010906 IMP regulation of glucose metabolic process
GO:0042304 IMP regulation of fatty acid biosynthetic process
GO:0042593 ISS glucose homeostasis
GO:0042594 ISS response to starvation
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045124 IEA regulation of bone resorption
GO:0046320 ISS regulation of fatty acid oxidation
GO:0071398 IMP cellular response to fatty acid
GO:0072593 IMP reactive oxygen species metabolic process
GO:2000811 IMP negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054848 pdk4 pyruvate dehydrogenase kinase, isozyme 4 protein_coding Danio_rerio
ENSMUSG00000019577 Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 protein_coding Mus_musculus

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