C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate dehydrogenase kinase, isoenzyme 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000019577 Pdk4 10090 - 6:5483351-5496309 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000019721 Pdk4-001 5483351-5496309 protein_coding
  ENSMUST00000134068 Pdk4-002 5494863-5496275 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000019721ENSMUST00000134068
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000019721 21.095±13.97 39.933±18.79 17.335±2.09 0.379±0.13 18.391±6.95 2.655±1.16 57.951±3.11 7.866±2.54 3.708±4.87 5.826±0.94 90.580±34.30 4.811±1.93 3.009±2.47 0.304±0.15
ENSMUST00000134068 27.843±19.69 41.407±14.20 N/A N/A 40.711±26.66 4.546±0.97 N/A 5.622±0.14 1.837±0.00 7.481±2.46 N/A 4.924±1.69 N/A 0.502±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008H4 CIL_0008H4_0002 VISTA 6:5207995-5812142
CIL_0006QC CIL_0006QC_0003 CGP 6:5383386-5496309
CIL_00053G CIL_00053G_0002 CGP 6:5483351-6028039

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004712 TAS protein serine/threonine/tyrosine kinase activity
GO:0004740 ISS pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 IEA ATP binding
GO:0005739 IDA mitochondrion
GO:0005743 IDA mitochondrial inner membrane
GO:0006006 IEA glucose metabolic process
GO:0006086 TAS acetyl-CoA biosynthetic process from pyruvate
GO:0006468 IEA protein phosphorylation
GO:0006885 IMP regulation of pH
GO:0008286 IMP insulin receptor signaling pathway
GO:0009267 ISS cellular response to starvation
GO:0010510 IMP regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565 IMP regulation of cellular ketone metabolic process
GO:0010906 IMP regulation of glucose metabolic process
GO:0042304 IMP regulation of fatty acid biosynthetic process
GO:0042593 IMP glucose homeostasis
GO:0042594 IMP response to starvation
GO:0045124 IMP regulation of bone resorption
GO:0046320 IMP regulation of fatty acid oxidation
GO:0071398 ISS cellular response to fatty acid
GO:0072593 ISS reactive oxygen species metabolic process
GO:2000811 IEA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054848 pdk4 pyruvate dehydrogenase kinase, isozyme 4 protein_coding Danio_rerio
ENSG00000004799 PDK4 pyruvate dehydrogenase kinase, isozyme 4 protein_coding Homo_sapiens

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