C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CREB binding protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005339 CREBBP 9606 - 16:3725054-3880726 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262367 CREBBP-001 3725054-3880726 protein_coding
  ENST00000382070 CREBBP-003 3727539-3880120 protein_coding
  ENST00000570939 CREBBP-008 3739614-3767832 protein_coding
  ENST00000571763 CREBBP-013 3731908-3736999 retained_intron
  ENST00000571826 CREBBP-006 3773636-3778172 protein_coding
  ENST00000572134 CREBBP-005 3773636-3780867 protein_coding
  ENST00000572569 CREBBP-009 3740443-3745654 retained_intron
  ENST00000573517 CREBBP-011 3739446-3751808 protein_coding
  ENST00000573672 CREBBP-007 3767302-3770703 retained_intron
  ENST00000574740 CREBBP-012 3736508-3744957 retained_intron
  ENST00000575237 CREBBP-010 3773740-3774746 retained_intron
  ENST00000576720 CREBBP-004 3731911-3743468 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262367ENST00000382070ENST00000571763
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262367 4.333±0.00 3.801±0.00 0.760±0.00 1.599±0.72 1.943±0.00 2.937±0.00 4.194±0.00 2.672±1.47 1.400±0.18 1.508±0.00 2.116±0.00 3.374±1.76 3.744±1.82 7.164±0.35
ENST00000382070 6.209±0.00 3.056±0.00 1.448±0.00 1.407±0.93 3.194±1.81 1.472±0.44 1.970±1.47 1.182±0.00 1.432±0.00 3.394±1.50 4.886±3.50 3.613±3.60 2.003±0.17 10.453±2.21
ENST00000571763 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.198±0.00 34.826±0.00 41.035±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00029G CIL_00029G_0002 CGP 16:3651639-3880726
CIL_00000C CIL_00000C_0002 CGP 16:3725054-4116185

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000123 IEA histone acetyltransferase complex
GO:0000790 IDA nuclear chromatin
GO:0000940 IEA condensed chromosome outer kinetochore
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001102 TAS RNA polymerase II activating transcription factor binding
GO:0001105 TAS RNA polymerase II transcription coactivator activity
GO:0001191 IDA RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0001666 TAS response to hypoxia
GO:0002039 IPI p53 binding
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 TAS sequence-specific DNA binding transcription factor activity
GO:0003712 IEA transcription cofactor activity
GO:0003713 IDA:IEA transcription coactivator activity
GO:0004402 IDA:IEA histone acetyltransferase activity
GO:0004871 TAS signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006325 TAS chromatin organization
GO:0006355 IDA:IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006461 TAS protein complex assembly
GO:0007165 NAS signal transduction
GO:0007219 TAS Notch signaling pathway
GO:0008134 IPI transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0008589 TAS regulation of smoothened signaling pathway
GO:0010467 TAS gene expression
GO:0016032 IEA viral process
GO:0016407 IDA acetyltransferase activity
GO:0016573 IDA:IEA histone acetylation
GO:0016604 IDA nuclear body
GO:0018076 IDA N-terminal peptidyl-lysine acetylation
GO:0030718 IEA germ-line stem cell maintenance
GO:0032481 TAS positive regulation of type I interferon production
GO:0042592 NAS homeostatic process
GO:0042733 TAS embryonic digit morphogenesis
GO:0043426 IDA MRF binding
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048511 IEA rhythmic process
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 TAS cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060976 CREBBP (1 of 3) CREB binding protein protein_coding Danio_rerio
ENSDARG00000061308 crebbpa CREB binding protein a protein_coding Danio_rerio
ENSDARG00000063102 crebbpb CREB binding protein b protein_coding Danio_rerio
ENSMUSG00000022521 Crebbp CREB binding protein protein_coding Mus_musculus

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