C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inhibitor of Bruton agammaglobulinemia tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005700 IBTK 9606 - 6:82169983-82247754 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306270 IBTK-001 82169983-82247754 protein_coding
  ENST00000369751 IBTK-004 82191331-82247754 retained_intron
  ENST00000445419 IBTK-008 82170239-82205929 retained_intron
  ENST00000471036 IBTK-003 82171508-82191854 nonsense_mediated_decay
  ENST00000503400 IBTK-005 82170743-82247671 nonsense_mediated_decay
  ENST00000503631 IBTK-006 82171403-82240565 protein_coding
  ENST00000505222 IBTK-002 82169986-82240565 retained_intron
  ENST00000508381 IBTK-010 82170236-82173578 retained_intron
  ENST00000510291 IBTK-007 82171412-82240565 protein_coding
  ENST00000610980 IBTK-201 82170239-82247754 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306270ENST00000369751ENST00000445419ENST00000503400ENST00000503631ENST00000508381ENST00000510291ENST00000610980
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306270 1.789±0.00 1.744±0.00 0.342±0.00 4.206±0.00 2.766±1.47 N/A 2.102±0.68 1.440±0.00 1.092±0.00 2.977±0.97 1.255±0.00 4.206±1.73 1.958±0.32 1.093±0.03
ENST00000369751 N/A N/A N/A N/A 2.975±0.00 3.110±0.00 0.910±0.00 N/A N/A 1.984±0.00 N/A 1.648±0.00 N/A N/A
ENST00000445419 N/A 1.100±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000503400 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.409±0.00 N/A N/A N/A
ENST00000503631 N/A N/A 0.569±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 1.844±0.00 N/A N/A
ENST00000508381 N/A 2.018±0.00 N/A N/A N/A N/A N/A N/A N/A 2.291±0.00 N/A N/A N/A 1.939±0.00
ENST00000510291 1.239±0.00 N/A 1.805±0.00 3.113±0.16 2.122±0.46 3.418±0.00 1.390±0.03 3.717±0.00 3.692±1.07 N/A 1.195±0.28 1.490±0.00 N/A 1.177±0.00
ENST00000610980 1.333±0.00 1.750±0.00 0.472±0.00 2.442±0.00 1.400±0.00 2.852±0.63 1.624±0.87 3.547±0.19 2.512±0.00 0.916±0.00 1.416±0.55 1.798±0.00 0.878±0.39 1.424±0.22

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006G7 CIL_0006G7_0001 CGP 6:81491439-82247754
CIL_0006GF CIL_0006GF_0001 CGP 6:82169983-82370828

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0016020 IEA membrane
GO:0019901 IDA protein kinase binding
GO:0030292 IDA protein tyrosine kinase inhibitor activity
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0061099 IDA negative regulation of protein tyrosine kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074424 ibtk inhibitor of Bruton agammaglobulinemia tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000035941 Ibtk inhibitor of Bruton agammaglobulinemia tyrosine kinase protein_coding Mus_musculus

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