C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pyruvate dehydrogenase kinase, isozyme 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005882 PDK2 9606 + 17:50094737-50112152 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000007708 PDK2-003 50094737-50111058 protein_coding
  ENST00000503076 PDK2-018 50106441-50108194 retained_intron
  ENST00000503176 PDK2-001 50095275-50112152 protein_coding
  ENST00000503614 PDK2-009 50095285-50108719 protein_coding
  ENST00000505440 PDK2-012 50095695-50107085 protein_coding
  ENST00000505897 PDK2-011 50095387-50106368 retained_intron
  ENST00000506242 PDK2-017 50105279-50107153 retained_intron
  ENST00000506647 PDK2-020 50108008-50109984 retained_intron
  ENST00000508030 PDK2-008 50094784-50106857 protein_coding
  ENST00000508960 PDK2-010 50095375-50097796 retained_intron
  ENST00000510219 PDK2-016 50104324-50108322 protein_coding
  ENST00000511026 PDK2-013 50095737-50097449 processed_transcript
  ENST00000512204 PDK2-019 50108001-50110209 retained_intron
  ENST00000512238 PDK2-014 50095974-50106039 protein_coding
  ENST00000515040 PDK2-015 50097513-50108245 retained_intron
  ENST00000614357 PDK2-201 50095695-50111368 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000503176ENST00000503614ENST00000505897ENST00000508030ENST00000508960ENST00000512204ENST00000515040
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000503176 N/A N/A N/A 0.157±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000503614 7.340±0.00 3.801±0.00 5.475±0.00 1.089±0.00 11.269±0.00 21.804±18.01 8.890±5.09 6.505±0.00 3.964±3.19 26.927±13.00 12.650±4.47 7.038±0.82
ENST00000505897 N/A N/A 6.344±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000508030 N/A N/A N/A N/A N/A 4.506±0.00 N/A N/A 3.319±0.00 N/A 25.550±0.00 N/A
ENST00000508960 N/A N/A N/A 1.162±0.00 N/A 5.654±0.00 5.360±0.00 N/A N/A 19.669±0.00 5.553±0.00 N/A
ENST00000512204 8.667±0.00 6.220±0.00 N/A 0.577±0.00 16.281±0.00 N/A 14.568±0.00 N/A 1.015±0.00 8.148±0.00 22.639±5.02 12.691±1.52
ENST00000515040 N/A N/A N/A N/A N/A 4.150±0.00 16.495±0.00 N/A N/A N/A 30.032±0.00 11.276±3.18

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00088W CIL_00088W_0001 VISTA 17:49956976-50560219

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 TAS protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004740 IDA pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 IEA protein binding
GO:0005524 IDA ATP binding
GO:0005739 IEA mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0005967 ISS mitochondrial pyruvate dehydrogenase complex
GO:0006006 IEA glucose metabolic process
GO:0006090 TAS pyruvate metabolic process
GO:0006111 ISS regulation of gluconeogenesis
GO:0006468 IEA protein phosphorylation
GO:0006885 ISS regulation of pH
GO:0008286 ISS insulin receptor signaling pathway
GO:0010510 ISS regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565 ISS regulation of cellular ketone metabolic process
GO:0010906 ISS regulation of glucose metabolic process
GO:0031670 ISS cellular response to nutrient
GO:0034614 IMP cellular response to reactive oxygen species
GO:0042593 ISS glucose homeostasis
GO:0042803 IPI protein homodimerization activity
GO:0044237 TAS cellular metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0072332 IMP intrinsic apoptotic signaling pathway by p53 class mediator

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020876 PDK2 (1 of 2) pyruvate dehydrogenase kinase, isozyme 2 protein_coding Danio_rerio
ENSDARG00000059054 pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 protein_coding Danio_rerio
ENSMUSG00000038967 Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 protein_coding Mus_musculus

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