C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000006071 ABCC8 9606 - 11:17392885-17476845 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302539 ABCC8-201 17392886-17476845 protein_coding
  ENST00000389817 ABCC8-001 17392885-17476845 protein_coding
  ENST00000524561 ABCC8-010 17402735-17407181 retained_intron
  ENST00000525022 ABCC8-014 17393041-17395915 retained_intron
  ENST00000526002 ABCC8-004 17430822-17443433 retained_intron
  ENST00000526037 ABCC8-018 17392885-17395780 retained_intron
  ENST00000526168 ABCC8-013 17392988-17395917 nonsense_mediated_decay
  ENST00000526921 ABCC8-008 17406677-17413552 retained_intron
  ENST00000527905 ABCC8-002 17396811-17476819 nonsense_mediated_decay
  ENST00000528202 ABCC8-005 17430597-17442791 processed_transcript
  ENST00000528374 ABCC8-012 17395921-17404538 protein_coding
  ENST00000529967 ABCC8-007 17406883-17414570 retained_intron
  ENST00000530147 ABCC8-009 17410246-17413536 retained_intron
  ENST00000531137 ABCC8-011 17396935-17404561 retained_intron
  ENST00000531642 ABCC8-015 17392885-17395885 nonsense_mediated_decay
  ENST00000531891 ABCC8-016 17396933-17402678 nonsense_mediated_decay
  ENST00000531911 ABCC8-006 17410597-17428093 retained_intron
  ENST00000532220 ABCC8-017 17395913-17397508 retained_intron
  ENST00000532728 ABCC8-003 17430564-17476807 retained_intron
  ENST00000612903 ABCC8-202 17470190-17476778 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302539ENST00000389817ENST00000524561ENST00000525022ENST00000526002ENST00000526037ENST00000526168ENST00000526921ENST00000527905ENST00000529967ENST00000531137ENST00000531642ENST00000531891ENST00000531911ENST00000532220ENST00000532728
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302539 N/A N/A 0.863±0.16 N/A N/A 0.132±0.10 N/A 0.009±0.00 N/A N/A 0.037±0.00 0.019±0.00 0.192±0.02
ENST00000389817 N/A 0.522±0.00 1.009±0.00 N/A N/A 0.037±0.00 N/A 0.008±0.00 N/A N/A 0.036±0.00 0.119±0.09 N/A
ENST00000524561 N/A N/A N/A 0.293±0.00 N/A N/A N/A 0.165±0.00 N/A N/A 0.140±0.00 N/A N/A
ENST00000525022 N/A N/A N/A N/A N/A N/A N/A 0.040±0.00 N/A N/A N/A N/A N/A
ENST00000526002 N/A N/A N/A N/A N/A 0.527±0.00 N/A 0.121±0.00 0.379±0.25 N/A N/A 0.253±0.00 N/A
ENST00000526037 N/A N/A N/A N/A 0.991±0.00 N/A N/A N/A N/A N/A 0.302±0.00 N/A N/A
ENST00000526168 N/A N/A N/A N/A N/A N/A 0.203±0.00 N/A 1.217±0.00 N/A 0.098±0.00 N/A N/A
ENST00000526921 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.157±0.00 0.308±0.00 N/A
ENST00000527905 N/A N/A 1.643±0.00 N/A 0.055±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000529967 0.102±0.00 N/A N/A 0.185±0.00 N/A N/A 0.104±0.00 N/A 0.467±0.00 0.244±0.00 0.189±0.00 0.088±0.02 N/A
ENST00000531137 N/A N/A N/A N/A 0.329±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000531642 N/A N/A N/A N/A N/A N/A 0.193±0.00 N/A N/A N/A N/A 0.152±0.00 N/A
ENST00000531891 N/A N/A N/A N/A N/A N/A N/A 0.152±0.05 N/A N/A 0.266±0.00 N/A N/A
ENST00000531911 0.171±0.00 N/A N/A N/A 0.261±0.00 N/A 0.133±0.00 N/A N/A N/A N/A N/A N/A
ENST00000532220 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.067±0.00 0.119±0.00 N/A
ENST00000532728 N/A N/A N/A N/A N/A 0.054±0.00 N/A N/A N/A N/A N/A 0.112±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003ZU CIL_0003ZU_0001 CGP 11:17385859-17476845
CIL_0003ZZ CIL_0003ZZ_0001 CGP 11:17392885-17544416

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005524 IEA ATP binding
GO:0005886 TAS plasma membrane
GO:0005975 NAS carbohydrate metabolic process
GO:0006112 TAS energy reserve metabolic process
GO:0006200 IEA ATP catabolic process
GO:0006810 IEA transport
GO:0006813 TAS potassium ion transport
GO:0007165 IEA signal transduction
GO:0007268 TAS synaptic transmission
GO:0008076 IDA voltage-gated potassium channel complex
GO:0008281 IEA sulfonylurea receptor activity
GO:0015079 TAS potassium ion transmembrane transporter activity
GO:0016021 IEA integral component of membrane
GO:0016887 IEA ATPase activity
GO:0042626 IEA ATPase activity, coupled to transmembrane movement of substances
GO:0044281 TAS small molecule metabolic process
GO:0044325 IPI ion channel binding
GO:0050796 TAS regulation of insulin secretion
GO:0055085 TAS:IEA transmembrane transport
GO:0071805 TAS potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000051879 abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 protein_coding Danio_rerio
ENSDARG00000076973 ABCC8 (2 of 3) ATP-binding cassette, sub-family C (CFTR/MRP), member 8 protein_coding Danio_rerio
ENSDARG00000077007 CABZ01071494.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000040136 Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 protein_coding Mus_musculus

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