C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: FYN proto-oncogene, Src family tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000010810 FYN 9606 - 6:111660332-111873452 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000229471 FYN-029 111661282-111759131 protein_coding
  ENST00000354650 FYN-001 111660332-111873452 protein_coding
  ENST00000368667 FYN-014 111661282-111793886 protein_coding
  ENST00000368678 FYN-017 111661286-111873430 protein_coding
  ENST00000368682 FYN-002 111660332-111873067 protein_coding
  ENST00000462598 FYN-010 111714430-111793912 protein_coding
  ENST00000462856 FYN-011 111702885-111759114 protein_coding
  ENST00000467899 FYN-005 111700187-111708227 retained_intron
  ENST00000467921 FYN-009 111661760-111696524 retained_intron
  ENST00000471959 FYN-008 111674465-111696815 retained_intron
  ENST00000476769 FYN-016 111696300-111709064 processed_transcript
  ENST00000484067 FYN-018 111714371-111873301 protein_coding
  ENST00000487824 FYN-024 111719858-111846615 protein_coding
  ENST00000491885 FYN-015 111661557-111676544 processed_transcript
  ENST00000495927 FYN-006 111702416-111707953 retained_intron
  ENST00000495935 FYN-007 111699935-111702986 retained_intron
  ENST00000496864 FYN-004 111696282-111714492 retained_intron
  ENST00000517419 FYN-028 111704020-111759917 protein_coding
  ENST00000518295 FYN-022 111704087-111873281 protein_coding
  ENST00000518630 FYN-019 111708011-111858383 protein_coding
  ENST00000520518 FYN-020 111703023-111873037 protein_coding
  ENST00000521062 FYN-013 111714382-111820078 protein_coding
  ENST00000521361 FYN-021 111719657-111819980 retained_intron
  ENST00000523238 FYN-012 111704088-111873440 protein_coding
  ENST00000523322 FYN-027 111702878-111759925 retained_intron
  ENST00000523570 FYN-023 111708017-111844944 protein_coding
  ENST00000523574 FYN-025 111707946-111798423 protein_coding
  ENST00000524310 FYN-026 111707930-111781080 protein_coding
  ENST00000538466 FYN-201 111660332-111720062 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000229471ENST00000354650ENST00000368667ENST00000368678ENST00000368682ENST00000467899ENST00000467921ENST00000471959ENST00000476769ENST00000484067ENST00000491885ENST00000495935ENST00000496864ENST00000517419
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000229471 N/A 9.157±0.00 N/A 20.896±0.00 9.777±0.00 7.239±0.00 3.773±0.00 N/A 1.293±0.00 N/A N/A N/A N/A 7.161±0.00
ENST00000354650 N/A 3.844±0.00 N/A 5.678±1.93 2.393±0.69 N/A 0.805±0.28 1.664±0.00 N/A N/A N/A 3.577±0.00 1.450±0.00 1.982±0.00
ENST00000368667 N/A 4.919±0.00 2.691±0.00 4.768±0.00 2.910±0.00 4.442±0.00 1.276±0.42 1.338±0.00 2.180±1.27 5.258±0.00 N/A 15.919±0.00 10.687±0.00 4.351±0.00
ENST00000368678 25.661±0.00 11.202±0.00 N/A 11.905±0.00 4.807±0.00 12.787±0.00 2.138±0.00 5.280±0.00 1.748±0.00 17.781±0.00 3.067±0.00 6.125±3.46 3.440±0.65 3.274±0.00
ENST00000368682 N/A N/A N/A N/A N/A 2.155±0.00 N/A N/A N/A 2.924±0.00 N/A 2.268±0.00 N/A 3.324±0.00
ENST00000467899 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.234±0.00 N/A N/A N/A
ENST00000467921 N/A 18.353±0.00 N/A 25.284±13.35 11.863±3.03 16.107±0.00 3.445±0.00 5.394±0.00 N/A 13.433±0.00 N/A 16.860±0.00 21.395±0.00 12.946±0.00
ENST00000471959 N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.625±0.00 N/A 7.134±0.00 N/A N/A
ENST00000476769 N/A N/A N/A N/A N/A 20.017±0.00 N/A N/A N/A N/A N/A N/A N/A 9.508±0.00
ENST00000484067 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 30.010±0.00 45.266±0.00 28.415±0.00
ENST00000491885 N/A 22.981±0.00 5.247±0.00 N/A 22.262±0.00 N/A N/A 6.931±0.00 7.601±0.00 N/A N/A N/A N/A 15.962±0.00
ENST00000495935 N/A N/A N/A N/A 19.330±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000496864 N/A N/A N/A N/A N/A N/A N/A 5.161±0.00 N/A N/A 5.484±0.00 N/A N/A N/A
ENST00000517419 N/A N/A 6.194±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000954 CIL_000954_0001 VISTA 6:111250485-111855465

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 IEA G-protein coupled receptor binding
GO:0001764 IEA neuron migration
GO:0001948 IPI glycoprotein binding
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 NAS non-membrane spanning protein tyrosine kinase activity
GO:0005102 IEA receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005739 IEA mitochondrion
GO:0005768 IDA endosome
GO:0005829 TAS cytosol
GO:0005884 IEA actin filament
GO:0005886 IDA plasma membrane
GO:0006468 NAS:IEA protein phosphorylation
GO:0006816 NAS calcium ion transport
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0007612 TAS learning
GO:0007631 TAS feeding behavior
GO:0008360 IEA regulation of cell shape
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010629 IEA negative regulation of gene expression
GO:0010976 IEA positive regulation of neuron projection development
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 IEA postsynaptic density
GO:0015631 IEA tubulin binding
GO:0016020 IEA membrane
GO:0016032 TAS viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030168 TAS platelet activation
GO:0030900 IEA forebrain development
GO:0031295 TAS T cell costimulation
GO:0032403 IEA protein complex binding
GO:0035556 TAS intracellular signal transduction
GO:0036120 IEA cellular response to platelet-derived growth factor stimulus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042493 IEA response to drug
GO:0042608 IEA T cell receptor binding
GO:0042609 IEA CD4 receptor binding
GO:0042610 IEA CD8 receptor binding
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0044325 IEA ion channel binding
GO:0045087 TAS innate immune response
GO:0045121 IDA membrane raft
GO:0045471 IEA response to ethanol
GO:0046777 IEA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0046875 IPI ephrin receptor binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048813 IEA dendrite morphogenesis
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050798 IEA activated T cell proliferation
GO:0050852 IDA T cell receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0051428 IEA peptide hormone receptor binding
GO:0070851 IPI growth factor receptor binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071944 IEA cell periphery
GO:1900182 IEA positive regulation of protein localization to nucleus
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011370 fyna FYN oncogene related to SRC, FGR, YES a protein_coding Danio_rerio
ENSDARG00000025319 fynb FYN oncogene related to SRC, FGR, YES b protein_coding Danio_rerio
ENSMUSG00000019843 Fyn Fyn proto-oncogene protein_coding Mus_musculus

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