C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Fyn proto-oncogene
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000019843 Fyn 10090 + 10:39368855-39565381 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000063091 Fyn-001 39369764-39565381 protein_coding
  ENSMUST00000099967 Fyn-002 39369798-39565372 protein_coding
  ENSMUST00000123205 Fyn-009 39533270-39551424 processed_transcript
  ENSMUST00000126486 Fyn-003 39369803-39564423 protein_coding
  ENSMUST00000135242 Fyn-004 39454805-39564355 protein_coding
  ENSMUST00000136659 Fyn-008 39511739-39564422 protein_coding
  ENSMUST00000146287 Fyn-005 39454915-39564355 protein_coding
  ENSMUST00000148152 Fyn-006 39368855-39515668 protein_coding
  ENSMUST00000157009 Fyn-007 39420009-39511859 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000063091ENSMUST00000099967ENSMUST00000123205ENSMUST00000126486ENSMUST00000135242ENSMUST00000136659ENSMUST00000146287ENSMUST00000148152
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000063091 4.847±0.00 N/A 1.130±0.00 N/A 8.832±2.35 3.956±1.61 N/A 1.422±0.51 2.068±0.98 9.268±1.98 0.238±0.00 18.213±7.41 1.556±0.01 1.746±0.69
ENSMUST00000099967 11.092±5.53 4.903±1.21 6.029±1.89 37.236±19.49 5.852±1.53 1.474±0.46 4.983±0.47 2.183±0.60 2.478±1.32 4.653±0.66 0.845±0.28 9.545±4.40 4.277±0.73 2.114±0.25
ENSMUST00000123205 N/A N/A N/A 192.440±0.00 N/A N/A N/A N/A N/A N/A N/A 170.539±0.00 105.766±3.07 50.814±0.00
ENSMUST00000126486 N/A 5.353±0.43 N/A N/A N/A 0.905±0.11 N/A 1.498±0.49 0.960±0.35 2.971±0.00 N/A N/A N/A 2.309±0.40
ENSMUST00000135242 10.469±3.15 N/A 8.548±3.91 49.133±5.93 7.920±0.83 N/A 5.656±2.15 1.847±0.87 5.174±2.99 5.182±0.00 0.907±0.31 18.527±4.96 6.402±2.32 3.314±1.09
ENSMUST00000136659 2.718±0.00 7.730±1.40 N/A 27.292±0.00 11.754±3.89 N/A 3.898±0.00 1.792±0.30 3.731±0.00 N/A 1.077±0.33 10.137±2.93 5.985±1.08 N/A
ENSMUST00000146287 N/A N/A N/A N/A 7.612±0.00 N/A 6.909±0.00 N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000148152 N/A N/A N/A N/A N/A N/A N/A N/A 1.929±0.00 N/A N/A 27.588±0.00 N/A 13.107±7.32

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000954 CIL_000954_0002 VISTA 10:39357714-39964005

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 IPI G-protein coupled receptor binding
GO:0001764 IMP neuron migration
GO:0001948 IEA glycoprotein binding
GO:0004672 IDA protein kinase activity
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005739 IEA mitochondrion
GO:0005768 IDA endosome
GO:0005829 TAS cytosol
GO:0005884 IDA actin filament
GO:0005886 IEA plasma membrane
GO:0006468 IMP protein phosphorylation
GO:0007166 IDA cell surface receptor signaling pathway
GO:0008360 IDA regulation of cell shape
GO:0010629 IMP negative regulation of gene expression
GO:0010976 IGI positive regulation of neuron projection development
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 IEA postsynaptic density
GO:0015631 IDA tubulin binding
GO:0016020 IEA membrane
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0030900 IMP forebrain development
GO:0032403 IEA protein complex binding
GO:0036120 IDA cellular response to platelet-derived growth factor stimulus
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042493 IEA response to drug
GO:0042552 TAS myelination
GO:0042608 IEA T cell receptor binding
GO:0042609 IEA CD4 receptor binding
GO:0042610 IEA CD8 receptor binding
GO:0043123 IGI positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0044325 IPI ion channel binding
GO:0045121 IEA membrane raft
GO:0045471 IGI response to ethanol
GO:0046777 IDA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0046875 IEA ephrin receptor binding
GO:0048813 IMP dendrite morphogenesis
GO:0050798 IMP activated T cell proliferation
GO:0050852 IEA T cell receptor signaling pathway
GO:0050966 IMP detection of mechanical stimulus involved in sensory perception of pain
GO:0051428 IEA peptide hormone receptor binding
GO:0070851 IEA growth factor receptor binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071944 IDA cell periphery
GO:1900182 IDA positive regulation of protein localization to nucleus
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011370 fyna FYN oncogene related to SRC, FGR, YES a protein_coding Danio_rerio
ENSDARG00000025319 fynb FYN oncogene related to SRC, FGR, YES b protein_coding Danio_rerio
ENSG00000010810 FYN FYN proto-oncogene, Src family tyrosine kinase protein_coding Homo_sapiens

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