C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000011566 MAP4K3 9606 - 2:39249266-39437312 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263881 MAP4K3-001 39249266-39437312 protein_coding
  ENST00000341681 MAP4K3-006 39249283-39437301 protein_coding
  ENST00000414968 MAP4K3-008 39293243-39325933 nonsense_mediated_decay
  ENST00000429397 MAP4K3-005 39325788-39437147 nonsense_mediated_decay
  ENST00000437545 MAP4K3-014 39249278-39379809 protein_coding
  ENST00000437968 MAP4K3-003 39337575-39437228 nonsense_mediated_decay
  ENST00000465701 MAP4K3-009 39290330-39299845 retained_intron
  ENST00000474502 MAP4K3-010 39290328-39294297 processed_transcript
  ENST00000475457 MAP4K3-012 39260691-39267425 retained_intron
  ENST00000479708 MAP4K3-013 39258523-39261117 retained_intron
  ENST00000484274 MAP4K3-002 39356165-39437065 protein_coding
  ENST00000495648 MAP4K3-011 39271911-39278419 retained_intron
  ENST00000497566 MAP4K3-007 39288215-39315517 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263881ENST00000341681ENST00000437545ENST00000484274
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263881 2.109±0.00 N/A N/A 1.349±0.23 1.130±0.00 1.010±0.00 1.121±0.36 1.484±0.00 0.699±0.40 1.197±0.00 N/A 3.180±0.24 1.670±0.55 3.324±0.00
ENST00000341681 3.367±0.00 2.356±0.00 1.790±0.00 2.492±1.50 1.995±0.27 1.734±0.43 4.307±0.00 2.335±1.54 1.776±0.58 4.246±0.00 3.332±0.80 3.882±0.41 2.650±0.95 3.749±0.00
ENST00000437545 N/A N/A 2.908±0.00 N/A N/A N/A 1.944±0.00 2.298±0.00 0.947±0.00 7.308±0.00 N/A 1.729±0.00 N/A N/A
ENST00000484274 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 21.505±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00067B CIL_00067B_0001 CGP 2:39175646-39437312
CIL_0003TC CIL_0003TC_0002 CGP 2:39249266-39717963

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005083 IEA small GTPase regulator activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0006468 IDA:IEA protein phosphorylation
GO:0007254 TAS JNK cascade
GO:0008152 IEA metabolic process
GO:0009411 IDA response to UV
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0034612 IDA response to tumor necrosis factor
GO:0035556 IDA intracellular signal transduction
GO:0050790 IEA regulation of catalytic activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071357 map4k3b mitogen-activated protein kinase kinase kinase kinase 3b protein_coding Danio_rerio
ENSDARG00000087742 MAP4K3 (2 of 2) mitogen-activated protein kinase kinase kinase kinase 3 protein_coding Danio_rerio
ENSMUSG00000024242 Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 protein_coding Mus_musculus

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