C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, ATPase, 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000013275 PSMC4 9606 + 19:39971005-39981441 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000157812 PSMC4-001 39971005-39981441 protein_coding
  ENST00000455878 PSMC4-002 39971170-39981441 protein_coding
  ENST00000593455 PSMC4-003 39971170-39981408 retained_intron
  ENST00000596386 PSMC4-006 39971192-39980061 retained_intron
  ENST00000601194 PSMC4-005 39979444-39980178 retained_intron
  ENST00000601697 PSMC4-004 39971180-39981441 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000157812ENST00000455878ENST00000593455ENST00000596386
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000157812 6.889±0.00 N/A 3.877±0.00 13.455±0.00 5.003±0.00 3.564±0.51 5.123±3.47 19.958±0.00 9.470±0.00 3.122±0.00 5.698±2.84 31.326±22.03 33.371±9.00 30.969±10.48
ENST00000455878 39.687±0.00 38.831±0.00 5.077±0.00 27.993±16.46 20.024±14.82 16.197±8.34 10.533±6.84 32.838±19.23 23.481±19.13 16.553±11.42 30.417±16.72 21.296±6.25 26.891±5.01 54.169±0.00
ENST00000593455 N/A 15.579±0.00 N/A 13.720±0.00 7.711±0.00 3.012±0.00 N/A N/A 6.970±0.00 12.551±0.00 N/A 6.487±0.00 N/A N/A
ENST00000596386 N/A N/A 3.227±0.00 N/A 3.996±0.00 3.576±0.00 3.769±0.00 7.651±0.00 6.936±0.00 N/A N/A 28.721±20.76 31.170±0.00 10.609±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0001824 IEA blastocyst development
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006200 TAS ATP catabolic process
GO:0006281 IEA DNA repair
GO:0006310 IEA DNA recombination
GO:0006508 TAS proteolysis
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0009378 IEA four-way junction helicase activity
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016234 IEA inclusion body
GO:0016787 IEA hydrolase activity
GO:0016887 TAS:IEA ATPase activity
GO:0022624 ISS proteasome accessory complex
GO:0030163 IEA protein catabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031597 IEA cytosolic proteasome complex
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027099 psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 protein_coding Danio_rerio
ENSMUSG00000030603 Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 protein_coding Mus_musculus

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