C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: spastin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000021574 SPAST 9606 + 2:32063611-32157637 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000315285 SPAST-001 32063707-32157637 protein_coding
  ENST00000345662 SPAST-002 32063611-32157636 protein_coding
  ENST00000615843 SPAST-201 32063611-32157636 protein_coding
  ENST00000621856 SPAST-003 32063968-32154496 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000315285ENST00000345662ENST00000615843ENST00000621856
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000315285 2.064±0.00 1.067±0.00 N/A N/A 0.657±0.00 1.396±0.00 0.509±0.00 1.089±0.67 0.775±0.35 N/A 1.508±0.00 3.085±0.00 0.973±0.26 3.905±0.00
ENST00000345662 0.579±0.00 1.034±0.00 N/A 3.598±0.06 1.525±0.88 1.457±0.00 0.638±0.13 N/A 0.586±0.10 1.286±0.08 1.049±0.52 2.517±1.53 1.559±0.46 0.786±0.21
ENST00000615843 N/A N/A N/A 2.108±0.00 N/A 0.878±0.00 N/A 1.722±0.00 N/A N/A N/A 1.973±0.00 N/A 3.658±0.00
ENST00000621856 N/A N/A 3.771±0.00 7.095±0.00 4.685±0.00 6.864±0.00 2.675±0.00 2.474±0.00 5.202±0.00 3.834±0.00 2.418±0.00 7.261±0.00 N/A 1.955±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000VL CIL_0000VL_0001 CGP 2:31867809-32157637
CIL_0000VK CIL_0000VK_0001 CGP 2:32063611-32224379

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001578 IDA microtubule bundle formation
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 IDA endosome
GO:0005783 IDA endoplasmic reticulum
GO:0005813 IEA centrosome
GO:0005874 IEA microtubule
GO:0006200 IEA ATP catabolic process
GO:0006281 IEA DNA repair
GO:0006310 IEA DNA recombination
GO:0006888 IMP ER to Golgi vesicle-mediated transport
GO:0007109 IMP cytokinesis, completion of separation
GO:0007409 IEA axonogenesis
GO:0008017 IDA microtubule binding
GO:0008219 IEA cell death
GO:0008568 IDA:IEA microtubule-severing ATPase activity
GO:0009378 IEA four-way junction helicase activity
GO:0015630 IDA microtubule cytoskeleton
GO:0016021 IEA integral component of membrane
GO:0030496 IDA midbody
GO:0031117 IEA positive regulation of microtubule depolymerization
GO:0031410 IDA cytoplasmic vesicle
GO:0034214 IDA protein hexamerization
GO:0043014 IPI alpha-tubulin binding
GO:0048487 IPI beta-tubulin binding
GO:0051013 IDA microtubule severing
GO:0051260 IDA protein homooligomerization
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024933 spast spastin protein_coding Danio_rerio
ENSMUSG00000024068 Spast spastin protein_coding Mus_musculus

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