C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Fas cell surface death receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000026103 FAS 9606 + 10:88990531-89015785 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000313771 FAS-015 88991288-89014177 processed_transcript
  ENST00000352159 FAS-016 88990687-89014955 protein_coding
  ENST00000355279 FAS-011 88990877-89014450 protein_coding
  ENST00000355740 FAS-005 88990657-89015785 protein_coding
  ENST00000357339 FAS-006 88990778-89014450 protein_coding
  ENST00000371857 FAS-014 88991431-89010952 retained_intron
  ENST00000460510 FAS-003 88990960-89008997 processed_transcript
  ENST00000466081 FAS-002 88991428-89010660 processed_transcript
  ENST00000477270 FAS-004 88991020-89010815 processed_transcript
  ENST00000479522 FAS-009 88990852-89014584 nonsense_mediated_decay
  ENST00000484444 FAS-008 88990731-89014619 nonsense_mediated_decay
  ENST00000487314 FAS-001 88991448-89012222 processed_transcript
  ENST00000488877 FAS-012 88990852-89014450 nonsense_mediated_decay
  ENST00000492756 FAS-010 88990877-89014450 nonsense_mediated_decay
  ENST00000494410 FAS-007 88990852-89014584 nonsense_mediated_decay
  ENST00000494799 FAS-013 88991443-89014216 processed_transcript
  ENST00000612663 FAS-201 88990531-89015784 protein_coding
  ENST00000615406 FAS-202 88990531-89015784 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainKidneyLungENST00000355279ENST00000355740
Transcript ID Brain Kidney Lung
ENST00000355279 N/A 2.996±0.00 N/A
ENST00000355740 1.181±0.53 1.810±0.00 7.100±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001IX CIL_0001IX_0001 CGP 10:88879734-88991390
CIL_0001VG CIL_0001VG_0001 CGP 10:88935074-89015785
CIL_0001IV CIL_0001IV_0001 CGP 10:88990531-89207314

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002377 IEA immunoglobulin production
GO:0003014 IEA renal system process
GO:0004871 TAS signal transducer activity
GO:0004872 NAS receptor activity
GO:0004888 IEA transmembrane signaling receptor activity
GO:0005515 IEA protein binding
GO:0005576 IEA extracellular region
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 NAS cytosol
GO:0005886 IDA plasma membrane
GO:0006461 TAS protein complex assembly
GO:0006915 IEA apoptotic process
GO:0006919 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006924 IEA activation-induced cell death of T cells
GO:0006925 IEA inflammatory cell apoptotic process
GO:0006927 IEA transformed cell apoptotic process
GO:0006955 IEA immune response
GO:0007165 IEA signal transduction
GO:0007623 IEA circadian rhythm
GO:0008625 IEA extrinsic apoptotic signaling pathway via death domain receptors
GO:0009636 IEA response to toxic substance
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010467 IEA gene expression
GO:0016021 IEA integral component of membrane
GO:0019724 IEA B cell mediated immunity
GO:0019900 IPI kinase binding
GO:0031264 IDA death-inducing signaling complex
GO:0031265 IDA CD95 death-inducing signaling complex
GO:0032464 IEA positive regulation of protein homooligomerization
GO:0042802 IPI identical protein binding
GO:0042981 NAS regulation of apoptotic process
GO:0043029 IEA T cell homeostasis
GO:0043065 IMP positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0045060 IEA negative thymic T cell selection
GO:0045121 IDA membrane raft
GO:0045619 IEA regulation of lymphocyte differentiation
GO:0045637 IEA regulation of myeloid cell differentiation
GO:0048536 IEA spleen development
GO:0050869 IEA negative regulation of B cell activation
GO:0051260 IEA protein homooligomerization
GO:0051384 IEA response to glucocorticoid
GO:0051402 IEA neuron apoptotic process
GO:0070062 IDA extracellular vesicular exosome
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071285 IEA cellular response to lithium ion
GO:0071455 IMP cellular response to hyperoxia
GO:0097049 IEA motor neuron apoptotic process
GO:0097190 TAS apoptotic signaling pathway
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand
GO:0097284 IEA hepatocyte apoptotic process
GO:0097527 IMP necroptotic signaling pathway
GO:2001239 TAS regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 IEA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043586 fas Fas (TNF receptor superfamily, member 6) protein_coding Danio_rerio
ENSMUSG00000024778 Fas Fas (TNF receptor superfamily member 6) protein_coding Mus_musculus

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