C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000049759 NEDD4L 9606 + 18:58044367-58401540 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000256830 NEDD4L-037 58044661-58396573 protein_coding
  ENST00000356462 NEDD4L-005 58044367-58396574 protein_coding
  ENST00000357895 NEDD4L-003 58149333-58396705 protein_coding
  ENST00000382850 NEDD4L-002 58044548-58401539 protein_coding
  ENST00000400345 NEDD4L-001 58044378-58396705 protein_coding
  ENST00000431212 NEDD4L-014 58221535-58396578 protein_coding
  ENST00000435432 NEDD4L-017 58149333-58396551 protein_coding
  ENST00000456173 NEDD4L-013 58195390-58398157 protein_coding
  ENST00000456986 NEDD4L-201 58047226-58401540 protein_coding
  ENST00000585323 NEDD4L-015 58221631-58316001 processed_transcript
  ENST00000585363 NEDD4L-008 58045934-58245508 processed_transcript
  ENST00000585594 NEDD4L-010 58054709-58165839 processed_transcript
  ENST00000585970 NEDD4L-041 58359871-58366231 processed_transcript
  ENST00000586263 NEDD4L-004 58149337-58396573 protein_coding
  ENST00000586268 NEDD4L-024 58221568-58329127 protein_coding
  ENST00000587190 NEDD4L-016 58221571-58322486 protein_coding
  ENST00000587246 NEDD4L-032 58366597-58373255 processed_transcript
  ENST00000587547 NEDD4L-011 58090791-58165839 processed_transcript
  ENST00000587634 NEDD4L-023 58247281-58323309 processed_transcript
  ENST00000587881 NEDD4L-030 58323320-58396333 protein_coding
  ENST00000588066 NEDD4L-018 58197769-58325082 processed_transcript
  ENST00000588494 NEDD4L-019 58195653-58323289 protein_coding
  ENST00000588516 NEDD4L-009 58046363-58245508 processed_transcript
  ENST00000588712 NEDD4L-034 58387711-58396580 retained_intron
  ENST00000589054 NEDD4L-022 58044384-58396704 protein_coding
  ENST00000589167 NEDD4L-027 58330851-58336092 retained_intron
  ENST00000590020 NEDD4L-026 58323305-58334020 retained_intron
  ENST00000590248 NEDD4L-036 58373170-58389519 retained_intron
  ENST00000590506 NEDD4L-035 58390064-58398157 retained_intron
  ENST00000590638 NEDD4L-028 58340959-58366073 retained_intron
  ENST00000590694 NEDD4L-007 58045525-58165861 processed_transcript
  ENST00000591579 NEDD4L-006 58045697-58165839 processed_transcript
  ENST00000591989 NEDD4L-039 58045689-58245489 processed_transcript
  ENST00000592097 NEDD4L-033 58373111-58391509 retained_intron
  ENST00000592601 NEDD4L-025 58314555-58329127 processed_transcript
  ENST00000592846 NEDD4L-020 58045707-58322471 protein_coding
  ENST00000617539 NEDD4L-042 58044387-58045477 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000256830ENST00000356462ENST00000357895ENST00000382850ENST00000400345ENST00000431212ENST00000456173ENST00000456986ENST00000586263ENST00000587881ENST00000590506ENST00000590638
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000256830 N/A N/A N/A N/A N/A N/A 0.933±0.00 N/A N/A N/A 1.806±0.00 N/A N/A N/A
ENST00000356462 2.321±0.00 0.725±0.00 N/A N/A N/A N/A N/A N/A 0.752±0.00 6.718±0.00 1.702±0.00 N/A N/A 3.090±0.00
ENST00000357895 N/A N/A N/A N/A 1.591±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000382850 N/A N/A 3.293±0.00 5.339±1.67 0.614±0.00 N/A N/A 0.862±0.00 0.563±0.09 2.582±0.00 2.288±0.00 1.074±0.37 0.921±0.00 1.197±0.00
ENST00000400345 1.382±0.00 N/A N/A N/A 1.295±0.00 N/A N/A N/A N/A N/A N/A 1.196±0.00 N/A N/A
ENST00000431212 N/A N/A N/A N/A N/A 3.945±0.00 N/A N/A N/A 8.108±0.13 N/A 2.005±0.13 3.600±0.63 N/A
ENST00000456173 N/A 0.305±0.00 4.827±0.00 4.828±0.00 N/A 4.220±0.00 N/A N/A 0.912±0.41 N/A N/A 1.849±0.00 N/A N/A
ENST00000456986 N/A N/A N/A N/A 0.697±0.00 2.414±0.00 N/A N/A 0.631±0.00 N/A N/A N/A N/A N/A
ENST00000586263 1.222±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000587881 N/A N/A N/A N/A N/A N/A 4.767±0.00 N/A N/A N/A 3.441±0.00 10.263±0.00 5.169±0.00 3.603±0.58
ENST00000590506 N/A N/A N/A N/A N/A N/A N/A 2.941±0.00 N/A N/A N/A N/A N/A N/A
ENST00000590638 N/A N/A 28.274±0.00 19.718±0.00 N/A N/A N/A N/A 6.412±0.00 32.522±0.00 N/A 9.207±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006OF CIL_0006OF_0001 CGP 18:57646426-58401540
CIL_0002BK CIL_0002BK_0001 CGP 18:58044367-58628957

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0003085 IEA negative regulation of systemic arterial blood pressure
GO:0003254 IDA regulation of membrane depolarization
GO:0004842 IEA ubiquitin-protein transferase activity
GO:0005515 IEA protein binding
GO:0005622 IC intracellular
GO:0005634 IBA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IBA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006513 IEA protein monoubiquitination
GO:0006814 NAS sodium ion transport
GO:0006883 NAS cellular sodium ion homeostasis
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007588 NAS excretion
GO:0009651 IEA response to salt stress
GO:0010038 IDA response to metal ion
GO:0010467 TAS gene expression
GO:0010765 IEA positive regulation of sodium ion transport
GO:0010766 IEA negative regulation of sodium ion transport
GO:0015459 IDA potassium channel regulator activity
GO:0016032 TAS viral process
GO:0016567 NAS protein ubiquitination
GO:0016874 IEA ligase activity
GO:0017080 IDA sodium channel regulator activity
GO:0019058 TAS viral life cycle
GO:0019870 IDA potassium channel inhibitor activity
GO:0019871 IDA sodium channel inhibitor activity
GO:0030104 NAS water homeostasis
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0034220 TAS ion transmembrane transport
GO:0034765 IDA regulation of ion transmembrane transport
GO:0042176 NAS regulation of protein catabolic process
GO:0042391 IDA regulation of membrane potential
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162 IEA ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044325 IPI ion channel binding
GO:0045732 IEA positive regulation of protein catabolic process
GO:0045807 NAS positive regulation of endocytosis
GO:0055085 TAS transmembrane transport
GO:0060306 IDA regulation of membrane repolarization
GO:0070062 IDA extracellular vesicular exosome
GO:0070936 IDA protein K48-linked ubiquitination
GO:0086005 ISS ventricular cardiac muscle cell action potential
GO:1901016 IDA regulation of potassium ion transmembrane transporter activity
GO:1901017 IDA negative regulation of potassium ion transmembrane transporter activity
GO:1901380 IDA negative regulation of potassium ion transmembrane transport
GO:1902306 IDA negative regulation of sodium ion transmembrane transport
GO:2000009 IDA negative regulation of protein localization to cell surface
GO:2000650 IDA negative regulation of sodium ion transmembrane transporter activity
GO:2000810 IEA regulation of tight junction assembly
GO:2001259 IEA positive regulation of cation channel activity
GO:2001288 ISS positive regulation of caveolin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060006 nedd4l neural precursor cell expressed, developmentally down-regulated 4-like protein_coding Danio_rerio
ENSMUSG00000024589 Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like protein_coding Mus_musculus

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