C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neural precursor cell expressed, developmentally down-regulated gene 4-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024589 Nedd4l 10090 + 18:64887756-65217826 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000080418 Nedd4l-201 65023527-65217826 protein_coding
  ENSMUST00000163516 Nedd4l-202 64887756-65217826 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000080418ENSMUST00000163516
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000080418 0.425±0.00 0.319±0.00 1.414±0.21 N/A 0.525±0.15 1.060±0.00 0.394±0.00 0.941±0.06 0.896±0.76 1.066±0.00 N/A 0.651±0.14 1.885±0.87 0.065±0.00
ENSMUST00000163516 2.563±1.19 1.359±0.40 2.353±0.65 6.559±0.57 1.833±0.59 5.369±0.58 0.663±0.06 4.836±0.57 0.412±0.17 3.860±1.13 0.576±0.01 1.803±0.31 1.645±0.93 0.207±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006OF CIL_0006OF_0002 CGP 18:64528979-65217826
CIL_0002BK CIL_0002BK_0002 CGP 18:64887756-65393888

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003085 IMP negative regulation of systemic arterial blood pressure
GO:0003254 IEA regulation of membrane depolarization
GO:0004842 IBA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IBA nucleus
GO:0005737 IBA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006513 IEA protein monoubiquitination
GO:0009651 IMP response to salt stress
GO:0010038 IEA response to metal ion
GO:0010765 IGI positive regulation of sodium ion transport
GO:0010766 IDA negative regulation of sodium ion transport
GO:0015459 IEA potassium channel regulator activity
GO:0016874 IEA ligase activity
GO:0017080 IEA sodium channel regulator activity
GO:0019870 IEA potassium channel inhibitor activity
GO:0019871 IDA sodium channel inhibitor activity
GO:0034765 IEA regulation of ion transmembrane transport
GO:0042391 IEA regulation of membrane potential
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162 IDA ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044325 IEA ion channel binding
GO:0045732 IEA positive regulation of protein catabolic process
GO:0060306 IEA regulation of membrane repolarization
GO:0070062 IEA extracellular vesicular exosome
GO:0070936 IEA protein K48-linked ubiquitination
GO:0086005 IEA ventricular cardiac muscle cell action potential
GO:1901016 IEA regulation of potassium ion transmembrane transporter activity
GO:1901017 IEA negative regulation of potassium ion transmembrane transporter activity
GO:1901380 IEA negative regulation of potassium ion transmembrane transport
GO:1902306 IEA negative regulation of sodium ion transmembrane transport
GO:2000009 IEA negative regulation of protein localization to cell surface
GO:2000650 IEA negative regulation of sodium ion transmembrane transporter activity
GO:2000810 IDA regulation of tight junction assembly
GO:2001259 IGI positive regulation of cation channel activity
GO:2001288 IEA positive regulation of caveolin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060006 nedd4l neural precursor cell expressed, developmentally down-regulated 4-like protein_coding Danio_rerio
ENSG00000049759 NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase protein_coding Homo_sapiens

Loading