C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000400345 NEDD4L-001 ENSG00000049759 9606 + 18:58044378-58396705 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBreastOvaryENST00000400345
Transcript ID Adipose Breast Ovary
ENST00000400345 1.382±0.00 1.295±0.00 1.196±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006OF CIL_0006OF_0001 CGP 18:57646426-58401540
CIL_0002BK CIL_0002BK_0001 CGP 18:58044367-58628957

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0003085 IEA negative regulation of systemic arterial blood pressure
GO:0003254 IDA regulation of membrane depolarization
GO:0004842 IBA:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IC intracellular
GO:0005634 IBA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IBA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006513 IEA protein monoubiquitination
GO:0006814 NAS sodium ion transport
GO:0006883 NAS cellular sodium ion homeostasis
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007588 NAS excretion
GO:0009651 IEA response to salt stress
GO:0010038 IDA response to metal ion
GO:0010467 TAS gene expression
GO:0010765 IEA positive regulation of sodium ion transport
GO:0010766 IEA negative regulation of sodium ion transport
GO:0015459 IDA potassium channel regulator activity
GO:0016032 TAS viral process
GO:0016567 NAS protein ubiquitination
GO:0016874 IEA ligase activity
GO:0017080 IDA sodium channel regulator activity
GO:0019058 TAS viral life cycle
GO:0019870 IDA potassium channel inhibitor activity
GO:0019871 IDA sodium channel inhibitor activity
GO:0030104 NAS water homeostasis
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0034220 TAS ion transmembrane transport
GO:0034765 IDA regulation of ion transmembrane transport
GO:0042176 NAS regulation of protein catabolic process
GO:0042391 IDA regulation of membrane potential
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162 IEA ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044325 IPI ion channel binding
GO:0045732 IEA positive regulation of protein catabolic process
GO:0045807 NAS positive regulation of endocytosis
GO:0055085 TAS transmembrane transport
GO:0060306 IDA regulation of membrane repolarization
GO:0070062 IDA extracellular vesicular exosome
GO:0070936 IDA protein K48-linked ubiquitination
GO:0086005 ISS ventricular cardiac muscle cell action potential
GO:1901016 IDA regulation of potassium ion transmembrane transporter activity
GO:1901017 IDA negative regulation of potassium ion transmembrane transporter activity
GO:1901380 IDA negative regulation of potassium ion transmembrane transport
GO:1902306 IDA negative regulation of sodium ion transmembrane transport
GO:2000009 IDA negative regulation of protein localization to cell surface
GO:2000650 IDA negative regulation of sodium ion transmembrane transporter activity
GO:2000810 IEA regulation of tight junction assembly
GO:2001259 IEA positive regulation of cation channel activity
GO:2001288 ISS positive regulation of caveolin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000163516 Nedd4l-202 protein_coding Mus_musculus 0 4128
ENSMUST00000080418 Nedd4l-201 protein_coding Mus_musculus 0 3921

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