C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cullin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000055130 CUL1 9606 + 7:148697914-148801036 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000325222 CUL1-002 148698912-148801036 protein_coding
  ENST00000409469 CUL1-001 148697914-148800582 protein_coding
  ENST00000602748 CUL1-003 148698645-148801025 protein_coding
  ENST00000617797 CUL1-201 148729999-148800707 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000325222ENST00000409469ENST00000602748ENST00000617797
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000325222 18.165±0.00 15.436±0.00 1.065±0.00 11.165±7.95 6.533±3.41 9.969±7.04 7.709±6.79 9.784±3.23 6.109±1.99 6.616±3.45 14.042±10.24 12.247±3.88 12.698±0.14 22.088±9.29
ENST00000409469 N/A N/A N/A N/A N/A N/A 2.494±0.00 N/A 4.626±0.00 N/A N/A 1.397±0.00 N/A N/A
ENST00000602748 N/A N/A N/A 5.210±0.00 N/A N/A N/A N/A N/A 2.519±0.00 N/A 3.665±0.56 2.314±0.00 31.775±13.44
ENST00000617797 N/A N/A N/A 2.472±0.00 3.560±1.10 2.521±0.00 N/A N/A N/A 2.328±0.00 N/A 1.290±0.00 3.296±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004XU CIL_0004XU_0001 CGP 7:148697914-148884321

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0005515 IPI protein binding
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006513 IEA protein monoubiquitination
GO:0006915 IEA apoptotic process
GO:0007050 TAS cell cycle arrest
GO:0007219 TAS Notch signaling pathway
GO:0008283 IEA cell proliferation
GO:0008285 TAS negative regulation of cell proliferation
GO:0009887 IEA organ morphogenesis
GO:0016032 IEA viral process
GO:0016567 IDA protein ubiquitination
GO:0019005 ISS SCF ubiquitin ligase complex
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146 ISS SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031461 IDA:IEA cullin-RING ubiquitin ligase complex
GO:0031625 IEA ubiquitin protein ligase binding
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1990452 IPI Parkin-FBXW7-Cul1 ubiquitin ligase complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007691 cul1b cullin 1b protein_coding Danio_rerio
ENSDARG00000019239 cul1a cullin 1a protein_coding Danio_rerio
ENSMUSG00000029686 Cul1 cullin 1 protein_coding Mus_musculus

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