C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leukocyte receptor tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000062524 LTK 9606 - 15:41503638-41513887 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263800 LTK-001 41503642-41513806 protein_coding
  ENST00000355166 LTK-002 41503638-41513879 protein_coding
  ENST00000453182 LTK-004 41503967-41513887 protein_coding
  ENST00000561619 LTK-005 41503951-41513796 protein_coding
  ENST00000563518 LTK-003 41503642-41513860 retained_intron
  ENST00000569283 LTK-006 41505258-41508236 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263800ENST00000355166ENST00000453182ENST00000561619ENST00000563518ENST00000569283
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263800 N/A 0.047±0.00 0.026±0.00 N/A 0.219±0.16 0.088±0.00 0.935±0.00 1.352±0.00 8.999±0.00 N/A 1.564±1.30 3.601±1.65 0.314±0.00
ENST00000355166 N/A N/A N/A 0.130±0.00 N/A N/A N/A N/A N/A N/A N/A 1.943±0.00 1.161±0.00
ENST00000453182 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.119±0.00 N/A N/A
ENST00000561619 0.018±0.00 N/A N/A 0.046±0.02 0.092±0.00 N/A N/A 0.297±0.00 N/A N/A N/A N/A 0.854±0.00
ENST00000563518 N/A N/A N/A N/A N/A N/A N/A 0.248±0.00 2.296±0.00 N/A N/A N/A N/A
ENST00000569283 0.021±0.00 0.410±0.00 N/A 0.073±0.00 N/A N/A N/A N/A N/A 0.682±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WJ CIL_0002WJ_0002 CGP 15:41493393-41513887
CIL_0005IS CIL_0005IS_0002 CGP 15:41503638-41544269

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IDA:IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005524 IEA ATP binding
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008283 IDA cell proliferation
GO:0010666 IDA positive regulation of cardiac muscle cell apoptotic process
GO:0010976 IMP positive regulation of neuron projection development
GO:0014065 IMP phosphatidylinositol 3-kinase signaling
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0043066 IMP negative regulation of apoptotic process
GO:0071300 IMP cellular response to retinoic acid

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042861 ltk leukocyte tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000027297 Ltk leukocyte tyrosine kinase protein_coding Mus_musculus

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