C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leukocyte tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027297 Ltk 10090 - 2:119751320-119760431 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028759 Ltk-001 119751326-119760431 protein_coding
  ENSMUST00000082130 Ltk-002 119751320-119760295 protein_coding
  ENSMUST00000127470 Ltk-004 119751322-119758521 retained_intron
  ENSMUST00000134295 Ltk-005 119751330-119758519 retained_intron
  ENSMUST00000140224 Ltk-003 119751320-119758525 protein_coding
  ENSMUST00000182203 Ltk-201 119751328-119758525 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028759ENSMUST00000082130ENSMUST00000127470ENSMUST00000134295ENSMUST00000140224ENSMUST00000182203
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028759 N/A 0.351±0.04 N/A N/A N/A 0.446±0.09 0.052±0.00 N/A 0.047±0.00 0.194±0.00 N/A 0.099±0.02 N/A N/A
ENSMUST00000082130 N/A N/A N/A N/A N/A 0.585±0.00 N/A 0.104±0.01 N/A N/A N/A N/A 0.313±0.00 N/A
ENSMUST00000127470 0.052±0.00 0.534±0.00 N/A 0.998±0.65 0.563±0.21 0.382±0.12 0.033±0.01 0.251±0.08 0.053±0.02 0.439±0.00 N/A 0.192±0.07 0.324±0.27 N/A
ENSMUST00000134295 0.126±0.13 N/A 0.073±0.01 0.912±0.62 1.688±0.29 0.441±0.10 0.055±0.00 0.360±0.13 0.093±0.08 0.638±0.16 N/A 0.289±0.15 0.365±0.22 N/A
ENSMUST00000140224 N/A 0.195±0.03 N/A 1.593±1.16 N/A N/A N/A N/A 0.055±0.04 N/A N/A 0.057±0.00 N/A N/A
ENSMUST00000182203 0.473±0.03 0.445±0.13 0.033±0.02 N/A 0.815±0.24 0.403±0.14 0.073±0.00 0.403±0.16 0.096±0.07 0.738±0.36 0.077±0.00 0.446±0.25 0.775±0.55 0.541±0.21

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WJ CIL_0002WJ_0003 CGP 2:119742337-119760431
CIL_0005IS CIL_0005IS_0003 CGP 2:119751320-119787537

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 ISS protein kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005524 IEA ATP binding
GO:0005783 IEA endoplasmic reticulum
GO:0005886 IEA plasma membrane
GO:0006468 ISS protein phosphorylation
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008283 ISS cell proliferation
GO:0010666 IEA positive regulation of cardiac muscle cell apoptotic process
GO:0010976 IEA positive regulation of neuron projection development
GO:0014065 ISS phosphatidylinositol 3-kinase signaling
GO:0016020 ISS membrane
GO:0016021 IEA integral component of membrane
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0043066 ISS negative regulation of apoptotic process
GO:0071300 IEA cellular response to retinoic acid

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042861 ltk leukocyte tyrosine kinase protein_coding Danio_rerio
ENSG00000062524 LTK leukocyte receptor tyrosine kinase protein_coding Homo_sapiens

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