C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: caspase 8, apoptosis-related cysteine peptidase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000064012 CASP8 9606 + 2:201233443-201287711 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264274 CASP8-201 201233443-201287711 protein_coding
  ENST00000264275 CASP8-006 201233466-201286729 protein_coding
  ENST00000323492 CASP8-012 201260500-201287709 protein_coding
  ENST00000339403 CASP8-007 201258324-201286656 retained_intron
  ENST00000358485 CASP8-002 201258036-201287711 protein_coding
  ENST00000392258 CASP8-004 201233506-201281915 protein_coding
  ENST00000392263 CASP8-009 201233443-201286594 protein_coding
  ENST00000392266 CASP8-202 201258091-201278161 protein_coding
  ENST00000413726 CASP8-023 201258118-201272942 protein_coding
  ENST00000424461 CASP8-016 201272638-201281859 protein_coding
  ENST00000429881 CASP8-026 201261956-201271559 protein_coding
  ENST00000432109 CASP8-014 201233463-201286594 protein_coding
  ENST00000437283 CASP8-001 201258118-201272738 nonsense_mediated_decay
  ENST00000440732 CASP8-021 201233502-201271584 protein_coding
  ENST00000444430 CASP8-017 201272638-201287092 protein_coding
  ENST00000447616 CASP8-010 201257980-201276904 protein_coding
  ENST00000450491 CASP8-020 201233486-201276968 protein_coding
  ENST00000471383 CASP8-015 201233470-201272919 retained_intron
  ENST00000490412 CASP8-011 201258119-201272725 processed_transcript
  ENST00000490682 CASP8-008 201233465-201242925 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264275ENST00000323492ENST00000339403ENST00000358485ENST00000392263ENST00000392266ENST00000413726ENST00000432109ENST00000444430ENST00000450491ENST00000490682
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264275 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.043±0.00 N/A N/A N/A
ENST00000323492 N/A 5.062±0.00 0.940±0.00 N/A N/A N/A 1.541±0.00 0.545±0.00 1.421±0.00 N/A 1.403±0.46 N/A N/A
ENST00000339403 1.536±0.00 12.216±0.00 N/A 2.028±0.55 1.943±0.00 N/A 1.618±0.00 0.678±0.00 N/A N/A 3.717±0.00 N/A 0.360±0.00
ENST00000358485 1.708±0.00 N/A N/A 1.727±0.00 N/A N/A 1.471±0.00 0.505±0.00 2.508±0.00 N/A 2.252±0.78 0.658±0.00 0.633±0.00
ENST00000392263 N/A N/A N/A N/A N/A N/A N/A 0.868±0.00 N/A 0.070±0.00 2.365±0.00 1.868±0.00 N/A
ENST00000392266 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.139±0.00 N/A N/A N/A
ENST00000413726 N/A N/A N/A N/A N/A 0.593±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000432109 N/A N/A N/A N/A N/A N/A 1.536±0.07 1.385±0.00 N/A 0.152±0.00 7.737±1.25 1.789±0.00 N/A
ENST00000444430 N/A N/A N/A N/A 0.416±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000450491 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.823±0.00 N/A
ENST00000490682 N/A N/A N/A N/A N/A N/A N/A N/A 0.665±0.00 N/A 2.916±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089O CIL_00089O_0001 VISTA 2:201132231-201734391

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001841 IEA neural tube formation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004175 IEA endopeptidase activity
GO:0004197 IEA:IDA cysteine-type endopeptidase activity
GO:0005123 IEA death receptor binding
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 TAS mitochondrial outer membrane
GO:0005815 IDA microtubule organizing center
GO:0005829 IDA cytosol
GO:0005856 TAS cytoskeleton
GO:0006508 IEA:IDA proteolysis
GO:0006915 IEA:IGI apoptotic process
GO:0006919 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007507 IEA heart development
GO:0008233 IMP peptidase activity
GO:0008234 TAS:IEA cysteine-type peptidase activity
GO:0008625 IBA extrinsic apoptotic signaling pathway via death domain receptors
GO:0009409 IEA response to cold
GO:0016032 IEA viral process
GO:0030101 TAS natural killer cell activation
GO:0030225 TAS macrophage differentiation
GO:0030690 IEA Noc1p-Noc2p complex
GO:0031264 IDA death-inducing signaling complex
GO:0031265 IDA CD95 death-inducing signaling complex
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032025 IEA response to cobalt ion
GO:0032355 IEA response to estradiol
GO:0032403 IEA protein complex binding
GO:0032496 IEA response to lipopolysaccharide
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034612 IMP response to tumor necrosis factor
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0035877 IPI death effector domain binding
GO:0036462 IDA TRAIL-activated apoptotic signaling pathway
GO:0042110 TAS T cell activation
GO:0042113 TAS B cell activation
GO:0042981 IEA regulation of apoptotic process
GO:0043005 IEA neuron projection
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0044297 IEA cell body
GO:0045087 TAS innate immune response
GO:0045121 IEA membrane raft
GO:0045471 IEA response to ethanol
GO:0045651 IMP positive regulation of macrophage differentiation
GO:0045862 IDA positive regulation of proteolysis
GO:0046677 IEA response to antibiotic
GO:0046982 IEA protein heterodimerization activity
GO:0051291 IEA protein heterooligomerization
GO:0051603 IMP proteolysis involved in cellular protein catabolic process
GO:0060546 IEA negative regulation of necroptotic process
GO:0060715 TAS syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0070243 IEA regulation of thymocyte apoptotic process
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0097110 IPI scaffold protein binding
GO:0097153 IMP cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 IMP apoptotic signaling pathway
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:0097194 IMP execution phase of apoptosis
GO:0097199 IMP cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097202 IDA activation of cysteine-type endopeptidase activity
GO:0097284 IEA hepatocyte apoptotic process
GO:0097342 IDA ripoptosome
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001233 IEA regulation of apoptotic signaling pathway
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway
GO:2001239 TAS regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070272 casp8l2 caspase 8, apoptosis-related cysteine peptidase, like 2 protein_coding Danio_rerio
ENSMUSG00000026029 Casp8 caspase 8 protein_coding Mus_musculus

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