C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: caspase 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026029 Casp8 10090 + 1:58795374-58847503 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027189 Casp8-001 58795374-58847503 protein_coding
  ENSMUST00000165549 Casp8-002 58802502-58847008 protein_coding
  ENSMUST00000190213 Casp8-003 58802653-58846754 protein_coding
  ENSMUST00000191201 Casp8-004 58795477-58846754 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027189ENSMUST00000165549ENSMUST00000190213ENSMUST00000191201
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027189 3.357±0.93 0.951±0.28 2.010±0.00 0.241±0.02 3.461±1.31 8.281±1.11 0.623±0.09 1.846±0.26 2.435±0.52 3.180±1.26 0.217±0.04 1.682±0.62 0.953±0.56 0.156±0.07
ENSMUST00000165549 1.947±1.29 0.442±0.25 6.267±0.96 0.494±0.35 2.056±0.51 N/A 0.573±0.21 1.932±0.75 2.995±1.86 2.224±1.23 0.814±0.43 4.634±4.35 2.646±0.79 0.175±0.04
ENSMUST00000190213 1.089±0.00 N/A 2.510±0.00 1.330±0.00 0.975±0.00 N/A N/A 0.982±0.21 0.677±0.00 1.356±0.00 0.519±0.09 10.175±9.46 5.060±4.12 0.572±0.34
ENSMUST00000191201 N/A 0.351±0.00 N/A 0.317±0.00 N/A N/A N/A N/A N/A N/A 0.216±0.08 2.253±1.78 1.143±0.00 0.371±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089O CIL_00089O_0002 VISTA 1:58652904-59256413

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IMP angiogenesis
GO:0001841 IMP neural tube formation
GO:0004175 IDA endopeptidase activity
GO:0004197 IDA cysteine-type endopeptidase activity
GO:0005123 IEA death receptor binding
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005815 IEA microtubule organizing center
GO:0005829 IEA cytosol
GO:0006915 IDA apoptotic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007507 IMP heart development
GO:0008233 IDA peptidase activity
GO:0008625 IMP extrinsic apoptotic signaling pathway via death domain receptors
GO:0009409 IEA response to cold
GO:0030225 IMP macrophage differentiation
GO:0030690 IMP Noc1p-Noc2p complex
GO:0031264 IEA death-inducing signaling complex
GO:0031265 IEA CD95 death-inducing signaling complex
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032025 IEA response to cobalt ion
GO:0032355 IEA response to estradiol
GO:0032403 IEA protein complex binding
GO:0032496 IEA response to lipopolysaccharide
GO:0034612 IEA response to tumor necrosis factor
GO:0035877 IBA death effector domain binding
GO:0036462 IEA TRAIL-activated apoptotic signaling pathway
GO:0043005 IEA neuron projection
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0044297 IEA cell body
GO:0045121 IEA membrane raft
GO:0045471 IEA response to ethanol
GO:0045651 IEA positive regulation of macrophage differentiation
GO:0045862 IEA positive regulation of proteolysis
GO:0046677 IEA response to antibiotic
GO:0046982 IPI protein heterodimerization activity
GO:0048738 TAS cardiac muscle tissue development
GO:0051291 IEA protein heterooligomerization
GO:0051603 IEA proteolysis involved in cellular protein catabolic process
GO:0060546 IGI negative regulation of necroptotic process
GO:0070243 IGI regulation of thymocyte apoptotic process
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0097110 IEA scaffold protein binding
GO:0097153 IDA cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 IDA apoptotic signaling pathway
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:0097194 ISS execution phase of apoptosis
GO:0097199 IEA cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097202 IEA activation of cysteine-type endopeptidase activity
GO:0097284 IMP hepatocyte apoptotic process
GO:0097342 ISS ripoptosome
GO:2001233 IGI regulation of apoptotic signaling pathway
GO:2001238 IGI positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070272 casp8l2 caspase 8, apoptosis-related cysteine peptidase, like 2 protein_coding Danio_rerio
ENSG00000064012 CASP8 caspase 8, apoptosis-related cysteine peptidase protein_coding Homo_sapiens

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