C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: caspase 8, apoptosis-related cysteine peptidase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000392263 CASP8-009 ENSG00000064012 9606 + 2:201233443-201286594 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; LiverMuscleOvaryPlacentaENST00000392263
Transcript ID Liver Muscle Ovary Placenta
ENST00000392263 0.868±0.00 0.070±0.00 2.365±0.00 1.868±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089O CIL_00089O_0001 VISTA 2:201132231-201734391

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004197 IEA:IDA cysteine-type endopeptidase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 TAS mitochondrial outer membrane
GO:0005815 IDA microtubule organizing center
GO:0005829 IDA cytosol
GO:0005856 TAS cytoskeleton
GO:0006508 IEA:IDA proteolysis
GO:0006915 IGI:IEA apoptotic process
GO:0006919 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0008233 IMP peptidase activity
GO:0008234 TAS:IEA cysteine-type peptidase activity
GO:0008625 IBA extrinsic apoptotic signaling pathway via death domain receptors
GO:0016032 IEA viral process
GO:0030101 TAS natural killer cell activation
GO:0030225 TAS macrophage differentiation
GO:0031264 IDA death-inducing signaling complex
GO:0031265 IDA CD95 death-inducing signaling complex
GO:0031625 IPI ubiquitin protein ligase binding
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034612 IMP response to tumor necrosis factor
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0035877 IPI death effector domain binding
GO:0036462 IDA TRAIL-activated apoptotic signaling pathway
GO:0042110 TAS T cell activation
GO:0042113 TAS B cell activation
GO:0042981 IEA regulation of apoptotic process
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0045651 IMP positive regulation of macrophage differentiation
GO:0045862 IDA positive regulation of proteolysis
GO:0051603 IMP proteolysis involved in cellular protein catabolic process
GO:0060715 TAS syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0071260 IEP cellular response to mechanical stimulus
GO:0097110 IPI scaffold protein binding
GO:0097153 IMP cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 IMP apoptotic signaling pathway
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:0097194 IMP execution phase of apoptosis
GO:0097199 IMP cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097202 IDA activation of cysteine-type endopeptidase activity
GO:0097342 IDA ripoptosome
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001239 TAS regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000190213 Casp8-003 protein_coding Mus_musculus 0 538
ENSMUST00000165549 Casp8-002 protein_coding Mus_musculus 0 538
ENSMUST00000191201 Casp8-004 protein_coding Mus_musculus 0 538
ENSMUST00000027189 Casp8-001 protein_coding Mus_musculus 0 538

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