C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: homeodomain interacting protein kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000064393 HIPK2 9606 - 7:139561570-139777778 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000342645 HIPK2-201 139583524-139717013 protein_coding
  ENST00000406875 HIPK2-001 139561570-139777718 protein_coding
  ENST00000428878 HIPK2-002 139572629-139777778 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000342645ENST00000406875ENST00000428878
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000342645 N/A N/A N/A 3.022±0.00 2.363±0.00 3.419±0.00 N/A N/A 4.040±0.00 4.511±0.00 4.444±0.00 N/A N/A
ENST00000406875 23.882±0.00 8.346±0.00 3.187±0.00 5.174±2.75 1.451±0.53 6.080±4.34 2.660±0.11 1.452±0.87 2.697±2.10 2.983±0.53 1.602±1.40 2.474±0.36 1.241±0.96
ENST00000428878 N/A 4.782±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00030C CIL_00030C_0001 CGP 7:139523856-139777778
CIL_00023M CIL_00023M_0002 CGP 7:139561570-140020325

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001102 ISS RNA polymerase II activating transcription factor binding
GO:0001105 ISS RNA polymerase II transcription coactivator activity
GO:0001654 ISS eye development
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0003714 IDA transcription corepressor activity
GO:0004672 IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006978 IDA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007224 IEA smoothened signaling pathway
GO:0007628 IEA adult walking behavior
GO:0008284 IEA positive regulation of cell proliferation
GO:0008344 IEA adult locomotory behavior
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0009952 IEA anterior/posterior pattern specification
GO:0010842 IEA retina layer formation
GO:0016020 IEA membrane
GO:0016604 IDA nuclear body
GO:0016605 IDA PML body
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 ISS peptidyl-serine phosphorylation
GO:0018107 ISS peptidyl-threonine phosphorylation
GO:0019048 NAS modulation by virus of host morphology or physiology
GO:0030182 IEA neuron differentiation
GO:0030218 ISS erythrocyte differentiation
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 IMP negative regulation of BMP signaling pathway
GO:0030578 TAS PML body organization
GO:0032092 ISS positive regulation of protein binding
GO:0042771 TAS intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043388 IEA positive regulation of DNA binding
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045766 IDA positive regulation of angiogenesis
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IMP positive regulation of JNK cascade
GO:0046332 IPI SMAD binding
GO:0046790 IPI virion binding
GO:0048596 IEA embryonic camera-type eye morphogenesis
GO:0050882 IEA voluntary musculoskeletal movement
GO:0051091 ISS positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726 TAS regulation of cell cycle
GO:0060059 IEA embryonic retina morphogenesis in camera-type eye
GO:0060235 IEA lens induction in camera-type eye
GO:0060395 IDA SMAD protein signal transduction
GO:0061072 IEA iris morphogenesis
GO:0071456 TAS cellular response to hypoxia
GO:0097193 NAS intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042518 hipk2 homeodomain interacting protein kinase 2 protein_coding Danio_rerio
ENSMUSG00000061436 Hipk2 homeodomain interacting protein kinase 2 protein_coding Mus_musculus

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