C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: homeodomain interacting protein kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000061436 Hipk2 10090 - 6:38694390-38876165 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000114855 Hipk2-005 38817907-38837311 retained_intron
  ENSMUST00000159307 Hipk2-006 38736699-38743260 processed_transcript
  ENSMUST00000159894 Hipk2-007 38745457-38818346 retained_intron
  ENSMUST00000160360 Hipk2-002 38697889-38875971 protein_coding
  ENSMUST00000160962 Hipk2-001 38697880-38837224 protein_coding
  ENSMUST00000161779 Hipk2-004 38694390-38876165 protein_coding
  ENSMUST00000162359 Hipk2-003 38697884-38875923 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000114855ENSMUST00000160360ENSMUST00000160962ENSMUST00000161779ENSMUST00000162359
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000114855 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.863±0.00 12.510±5.00
ENSMUST00000160360 3.288±0.00 11.145±2.53 N/A 5.669±0.98 2.641±0.28 N/A 5.093±1.11 3.473±0.73 7.653±1.70 6.399±2.13 N/A 1.820±0.00
ENSMUST00000160962 N/A N/A N/A N/A 1.781±0.00 N/A N/A 3.286±0.00 N/A 6.768±1.33 N/A N/A
ENSMUST00000161779 2.771±0.33 22.058±3.53 5.807±2.89 13.737±5.53 4.657±1.57 2.177±0.00 4.884±1.82 2.412±0.95 12.360±6.73 12.383±2.95 0.778±0.00 1.756±0.18
ENSMUST00000162359 N/A 11.442±3.12 N/A 7.402±0.61 2.531±0.95 N/A N/A 2.764±0.39 N/A 6.711±2.18 0.721±0.00 1.226±0.29

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00030C CIL_00030C_0002 CGP 6:38663069-38876165
CIL_00023M CIL_00023M_0003 CGP 6:38694390-39084585

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001105 IMP RNA polymerase II transcription coactivator activity
GO:0001934 IGI positive regulation of protein phosphorylation
GO:0003714 IDA transcription corepressor activity
GO:0004672 IDA protein kinase activity
GO:0004674 ISA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006468 IDA protein phosphorylation
GO:0006978 IEA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0007224 IGI smoothened signaling pathway
GO:0007628 IMP adult walking behavior
GO:0008284 IGI positive regulation of cell proliferation
GO:0008344 IMP adult locomotory behavior
GO:0009952 IGI anterior/posterior pattern specification
GO:0010842 IMP retina layer formation
GO:0016604 IEA nuclear body
GO:0016605 TAS PML body
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0030182 IMP neuron differentiation
GO:0030511 ISS positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0032092 IDA positive regulation of protein binding
GO:0042771 IGI intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043388 IDA positive regulation of DNA binding
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0045766 IEA positive regulation of angiogenesis
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046330 ISS positive regulation of JNK cascade
GO:0046332 IEA SMAD binding
GO:0046790 ISS virion binding
GO:0048596 IMP embryonic camera-type eye morphogenesis
GO:0050882 IMP voluntary musculoskeletal movement
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060059 IMP embryonic retina morphogenesis in camera-type eye
GO:0060235 IMP lens induction in camera-type eye
GO:0060395 IEA SMAD protein signal transduction
GO:0061072 IMP iris morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042518 hipk2 homeodomain interacting protein kinase 2 protein_coding Danio_rerio
ENSG00000064393 HIPK2 homeodomain interacting protein kinase 2 protein_coding Homo_sapiens

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