C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000066056 TIE1 9606 + 1:43300993-43323108 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000372476 TIE1-001 43300993-43323108 protein_coding
  ENST00000461061 TIE1-008 43313188-43315291 processed_transcript
  ENST00000471187 TIE1-007 43313174-43314150 processed_transcript
  ENST00000473014 TIE1-003 43313292-43320880 processed_transcript
  ENST00000480269 TIE1-005 43307142-43309045 processed_transcript
  ENST00000485125 TIE1-004 43302450-43305343 processed_transcript
  ENST00000488437 TIE1-006 43309047-43312601 processed_transcript
  ENST00000492599 TIE1-009 43317930-43319482 processed_transcript
  ENST00000492874 TIE1-010 43319463-43320423 processed_transcript
  ENST00000538015 TIE1-201 43301072-43308968 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000372476ENST00000473014ENST00000488437ENST00000538015
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000372476 52.616±0.00 39.280±0.00 1.149±0.00 1.439±0.61 12.220±10.25 13.009±12.52 5.141±4.26 4.370±2.79 2.338±0.76 20.844±18.13 3.854±2.77 6.774±4.97 67.347±31.18 5.024±2.97
ENST00000473014 N/A N/A N/A 0.513±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.787±0.00
ENST00000488437 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.817±0.00 4.752±0.00
ENST00000538015 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.558±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008N2 CIL_0008N2_0001 VISTA 1:42758169-43359178

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001568 IEA blood vessel development
GO:0001570 IEA vasculogenesis
GO:0001701 IEA in utero embryonic development
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005886 IEA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007498 TAS mesoderm development
GO:0016525 IEA negative regulation of angiogenesis
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030336 IEA negative regulation of cell migration
GO:0032526 IEA response to retinoic acid
GO:0045026 IEA plasma membrane fusion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004105 tie1 endothelium-specific receptor tyrosine kinase 1 protein_coding Danio_rerio
ENSMUSG00000033191 Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 protein_coding Mus_musculus

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