C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000033191 Tie1 10090 - 4:118471191-118490061 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000047421 Tie1-001 118471191-118490061 protein_coding
  ENSMUST00000153286 Tie1-003 118478032-118489793 processed_transcript
  ENSMUST00000184261 Tie1-002 118471191-118489755 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000047421ENSMUST00000153286ENSMUST00000184261
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000047421 30.364±11.54 20.842±5.36 9.091±0.79 5.852±1.84 16.895±4.30 8.290±1.32 19.392±1.19 17.749±2.05 4.663±1.56 84.049±26.89 6.224±0.62 18.723±5.88 8.387±3.43 0.567±0.24
ENSMUST00000153286 4.386±0.87 17.982±5.59 N/A N/A 9.626±3.80 2.319±0.00 4.992±0.93 N/A N/A 41.195±3.58 N/A 6.045±1.05 8.608±2.06 0.087±0.00
ENSMUST00000184261 5.718±2.20 N/A 1.521±0.18 N/A N/A 1.291±0.00 4.093±1.36 2.970±0.00 N/A N/A 1.364±0.28 2.497±0.30 1.675±0.49 0.085±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003N3 CIL_0003N3_0002 CGP 4:118442415-118490061

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001568 IMP blood vessel development
GO:0001570 IEA vasculogenesis
GO:0001701 IGI in utero embryonic development
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005524 IEA ATP binding
GO:0005886 IDA plasma membrane
GO:0016021 ISM integral component of membrane
GO:0016525 IMP negative regulation of angiogenesis
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030336 IMP negative regulation of cell migration
GO:0032526 IDA response to retinoic acid
GO:0045026 IMP plasma membrane fusion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004105 tie1 endothelium-specific receptor tyrosine kinase 1 protein_coding Danio_rerio
ENSG00000066056 TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 protein_coding Homo_sapiens

Loading