C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neuronal guanine nucleotide exchange factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000066248 NGEF 9606 - 2:232878686-233013272 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264051 NGEF-001 232878686-233013272 protein_coding
  ENST00000373552 NGEF-003 232879215-232928154 protein_coding
  ENST00000409079 NGEF-002 232894602-232928154 protein_coding
  ENST00000414326 NGEF-010 232970043-232974796 protein_coding
  ENST00000416114 NGEF-004 232885323-232901462 protein_coding
  ENST00000420650 NGEF-006 232892898-232905849 protein_coding
  ENST00000424488 NGEF-008 232882229-232890980 protein_coding
  ENST00000458735 NGEF-005 232891349-232901440 protein_coding
  ENST00000461944 NGEF-007 232884924-232890980 retained_intron
  ENST00000489127 NGEF-009 232882253-232885536 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainKidneyLiverENST00000264051ENST00000373552
Transcript ID Brain Kidney Liver
ENST00000264051 N/A 4.380±0.00 6.696±0.00
ENST00000373552 34.190±16.55 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003HQ CIL_0003HQ_0001 CGP 2:232766464-232878708
CIL_0003HR CIL_0003HR_0001 CGP 2:232857270-233013272
CIL_0003HS CIL_0003HS_0001 CGP 2:232878686-233035057

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005829 TAS cytosol
GO:0007264 TAS small GTPase mediated signal transduction
GO:0009987 IEA cellular process
GO:0016020 IEA membrane
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0042995 IEA cell projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043087 ISS regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048013 ISS ephrin receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0061002 ISS negative regulation of dendritic spine morphogenesis
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076179 NGEF neuronal guanine nucleotide exchange factor protein_coding Danio_rerio
ENSMUSG00000026259 Ngef neuronal guanine nucleotide exchange factor protein_coding Mus_musculus

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