C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neuronal guanine nucleotide exchange factor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000264051 NGEF-001 ENSG00000066248 9606 - 2:232878686-233013272 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; KidneyLiverENST00000264051
Transcript ID Kidney Liver
ENST00000264051 4.380±0.00 6.696±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003HQ CIL_0003HQ_0001 CGP 2:232766464-232878708
CIL_0003HR CIL_0003HR_0001 CGP 2:232857270-233013272
CIL_0003HS CIL_0003HS_0001 CGP 2:232878686-233035057

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005829 TAS cytosol
GO:0007264 TAS small GTPase mediated signal transduction
GO:0009987 IEA cellular process
GO:0016020 IEA membrane
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0042995 IEA cell projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043087 ISS regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048013 ISS ephrin receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0061002 ISS negative regulation of dendritic spine morphogenesis
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000068681 Ngef-001 protein_coding Mus_musculus 0 2054
ENSMUST00000027477 Ngef-002 protein_coding Mus_musculus 0 2013
ENSMUST00000168235 Ngef-003 protein_coding Mus_musculus 0 852
ENSMUST00000166463 Ngef-004 retained_intron Mus_musculus 0 806

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