C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neuronal guanine nucleotide exchange factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026259 Ngef 10090 - 1:87476834-87573870 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027477 Ngef-002 87476834-87510362 protein_coding
  ENSMUST00000068681 Ngef-001 87476834-87573870 protein_coding
  ENSMUST00000166463 Ngef-004 87479729-87486217 retained_intron
  ENSMUST00000168235 Ngef-003 87478685-87486177 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000027477ENSMUST00000068681ENSMUST00000166463ENSMUST00000168235
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000027477 0.668±0.52 0.127±0.06 1.992±0.26 44.642±58.08 0.436±0.17 N/A 0.183±0.04 N/A 0.568±0.00 1.779±0.26 3.456±1.13 0.457±0.35 0.345±0.17
ENSMUST00000068681 0.903±0.16 0.040±0.01 0.570±0.00 N/A 0.428±0.15 7.687±1.08 0.159±0.07 11.154±2.50 5.983±2.30 1.602±0.40 2.093±1.03 0.236±0.11 N/A
ENSMUST00000166463 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.229±0.00 0.682±0.20 1.314±0.00
ENSMUST00000168235 N/A 0.092±0.02 N/A 41.569±0.00 N/A 4.921±0.00 0.051±0.00 N/A 5.253±0.90 N/A 2.816±0.00 1.310±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003HR CIL_0003HR_0002 CGP 1:87470271-87573870
CIL_0003HS CIL_0003HS_0002 CGP 1:87476834-87597845

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0009987 IDA cellular process
GO:0016020 IEA membrane
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0042995 IEA cell projection
GO:0043087 IDA regulation of GTPase activity
GO:0046875 IPI ephrin receptor binding
GO:0048013 IDA ephrin receptor signaling pathway
GO:0061002 IDA negative regulation of dendritic spine morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076179 NGEF neuronal guanine nucleotide exchange factor protein_coding Danio_rerio
ENSG00000066248 NGEF neuronal guanine nucleotide exchange factor protein_coding Homo_sapiens

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