C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: RAR-related orphan receptor A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000069667 RORA 9606 - 15:60488284-61229319 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261523 RORA-003 60497264-60627463 protein_coding
  ENST00000309157 RORA-002 60497264-60627444 protein_coding
  ENST00000335670 RORA-001 60488284-61229319 protein_coding
  ENST00000449337 RORA-005 60497285-60592541 protein_coding
  ENST00000551975 RORA-004 60511294-61229133 nonsense_mediated_decay
  ENST00000557822 RORA-008 60531528-61229243 retained_intron
  ENST00000558234 RORA-006 60528073-60592517 retained_intron
  ENST00000558904 RORA-014 61176068-61229155 protein_coding
  ENST00000559145 RORA-010 60650621-61229225 processed_transcript
  ENST00000559343 RORA-009 60511592-60593126 protein_coding
  ENST00000559587 RORA-007 60505606-60512097 processed_transcript
  ENST00000560004 RORA-012 60511457-60706352 processed_transcript
  ENST00000560300 RORA-013 61038826-61229233 processed_transcript
  ENST00000561093 RORA-011 60678224-61229231 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000335670ENST00000449337ENST00000558234
Transcript ID Adipose Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000335670 0.478±0.00 1.467±0.00 0.620±0.00 N/A N/A N/A 0.390±0.00 N/A 1.436±0.00 N/A 0.088±0.00 1.211±0.00
ENST00000449337 N/A N/A 6.771±0.00 3.120±0.00 2.853±0.00 12.477±0.00 N/A N/A 5.039±0.00 2.353±1.43 0.330±0.13 9.313±0.00
ENST00000558234 N/A N/A N/A N/A N/A N/A N/A 4.595±0.00 N/A 2.056±0.00 0.153±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007LQ CIL_0007LQ_0001 UCNEbase 15:59905203-60532122

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001222 IPI transcription corepressor binding
GO:0001223 IPI transcription coactivator binding
GO:0001525 IMP angiogenesis
GO:0003677 IDA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA:IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006805 ISS xenobiotic metabolic process
GO:0006809 IEA nitric oxide biosynthetic process
GO:0007623 IEA circadian rhythm
GO:0008013 IEA beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008142 IDA oxysterol binding
GO:0008270 IEA zinc ion binding
GO:0008589 ISS regulation of smoothened signaling pathway
GO:0010467 TAS gene expression
GO:0010575 IMP positive regulation vascular endothelial growth factor production
GO:0010906 ISS regulation of glucose metabolic process
GO:0019218 ISS regulation of steroid metabolic process
GO:0021702 IEA cerebellar Purkinje cell differentiation
GO:0021930 ISS cerebellar granule cell precursor proliferation
GO:0030522 IDA intracellular receptor signaling pathway
GO:0032922 ISS circadian regulation of gene expression
GO:0036315 IMP cellular response to sterol
GO:0042692 IMP muscle cell differentiation
GO:0042752 IEA regulation of circadian rhythm
GO:0042753 ISS positive regulation of circadian rhythm
GO:0043030 IEA regulation of macrophage activation
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IDA:IEA sequence-specific DNA binding
GO:0045599 ISS negative regulation of fat cell differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046068 IEA cGMP metabolic process
GO:0050728 IMP negative regulation of inflammatory response
GO:0060850 ISS regulation of transcription involved in cell fate commitment
GO:0070328 IMP triglyceride homeostasis
GO:0071456 IMP cellular response to hypoxia
GO:0072539 ISS T-helper 17 cell differentiation
GO:0098531 IDA direct ligand regulated sequence-specific DNA binding transcription factor activity
GO:2000188 ISS regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031768 roraa RAR-related orphan receptor A, paralog a protein_coding Danio_rerio
ENSMUSG00000032238 Rora RAR-related orphan receptor alpha protein_coding Mus_musculus

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