C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: GLI family zinc finger 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000074047 GLI2 9606 + 2:120735623-120992653 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000314490 GLI2-201 120797226-120988485 protein_coding
  ENST00000341310 GLI2-006 120792283-120991380 nonsense_mediated_decay
  ENST00000360874 GLI2-012 120797345-120970489 protein_coding
  ENST00000361492 GLI2-202 120797291-120992652 protein_coding
  ENST00000418323 GLI2-007 120736247-120927458 protein_coding
  ENST00000433812 GLI2-011 120797345-120975034 nonsense_mediated_decay
  ENST00000435313 GLI2-008 120797296-120986435 processed_transcript
  ENST00000437950 GLI2-004 120797291-120988485 nonsense_mediated_decay
  ENST00000438299 GLI2-001 120792283-120991380 nonsense_mediated_decay
  ENST00000445186 GLI2-005 120792283-120991380 nonsense_mediated_decay
  ENST00000452319 GLI2-009 120792409-120992653 protein_coding
  ENST00000452692 GLI2-002 120792283-120991380 nonsense_mediated_decay
  ENST00000472722 GLI2-015 120735623-120951763 retained_intron
  ENST00000482119 GLI2-014 120735623-120951466 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000341310ENST00000361492ENST00000433812ENST00000435313ENST00000437950ENST00000445186ENST00000452692ENST00000482119
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000341310 N/A N/A N/A 0.040±0.00 0.316±0.00 N/A N/A N/A N/A N/A 0.342±0.00 0.208±0.00 0.178±0.00
ENST00000361492 0.139±0.00 0.386±0.00 0.051±0.00 0.386±0.00 0.169±0.00 0.482±0.00 N/A N/A 0.019±0.00 N/A 3.602±1.41 0.343±0.07 0.389±0.00
ENST00000433812 N/A N/A N/A 0.056±0.00 N/A N/A 0.275±0.00 N/A N/A 1.241±0.00 N/A N/A N/A
ENST00000435313 N/A N/A 0.397±0.00 N/A 1.049±0.00 0.351±0.00 N/A N/A 0.986±0.00 N/A 1.268±0.00 0.427±0.19 0.526±0.00
ENST00000437950 N/A N/A N/A 0.022±0.00 N/A N/A 0.073±0.00 N/A N/A N/A N/A N/A N/A
ENST00000445186 N/A N/A N/A N/A N/A 0.118±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000452692 N/A N/A 0.083±0.00 N/A 0.218±0.00 N/A N/A 0.087±0.00 N/A N/A 0.493±0.00 N/A N/A
ENST00000482119 N/A N/A N/A N/A N/A N/A N/A 2.159±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081M CIL_00081M_0001 VISTA 2:120504710-121107153
CIL_00081M CIL_00081M_0002 VISTA 2:120507154-121108132

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001501 ISS skeletal system development
GO:0001649 IDA osteoblast differentiation
GO:0001701 IEA in utero embryonic development
GO:0001822 ISS kidney development
GO:0002009 IEA morphogenesis of an epithelium
GO:0002062 IEA chondrocyte differentiation
GO:0002076 ISS osteoblast development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005929 IEA cilium
GO:0006351 IEA transcription, DNA-templated
GO:0007224 IDA smoothened signaling pathway
GO:0007389 ISS pattern specification process
GO:0007411 ISS axon guidance
GO:0007418 ISS ventral midline development
GO:0007442 ISS hindgut morphogenesis
GO:0007507 ISS heart development
GO:0008270 IDA zinc ion binding
GO:0008283 IDA cell proliferation
GO:0008284 IEA positive regulation of cell proliferation
GO:0008589 IEA regulation of smoothened signaling pathway
GO:0009612 IEA response to mechanical stimulus
GO:0009913 IDA epidermal cell differentiation
GO:0009953 IEA dorsal/ventral pattern formation
GO:0009954 ISS proximal/distal pattern formation
GO:0016020 IEA membrane
GO:0016607 IEA nuclear speck
GO:0021508 ISS floor plate formation
GO:0021513 ISS spinal cord dorsal/ventral patterning
GO:0021517 ISS ventral spinal cord development
GO:0021522 IEA spinal cord motor neuron differentiation
GO:0021696 ISS cerebellar cortex morphogenesis
GO:0021775 ISS smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776 IEA smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021904 IEA dorsal/ventral neural tube patterning
GO:0021915 IEA neural tube development
GO:0021938 IEA smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021965 ISS spinal cord ventral commissure morphogenesis
GO:0021983 ISS pituitary gland development
GO:0030154 IEA cell differentiation
GO:0030324 ISS lung development
GO:0030879 ISS mammary gland development
GO:0030902 ISS hindbrain development
GO:0031512 IEA motile primary cilium
GO:0032331 IEA negative regulation of chondrocyte differentiation
GO:0033089 ISS positive regulation of T cell differentiation in thymus
GO:0035295 ISS tube development
GO:0042475 ISS odontogenesis of dentin-containing tooth
GO:0042733 IEA embryonic digit morphogenesis
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045740 IDA positive regulation of DNA replication
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048566 ISS embryonic digestive tract development
GO:0048589 ISS developmental growth
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0048666 ISS neuron development
GO:0048754 ISS branching morphogenesis of an epithelial tube
GO:0048856 IEA anatomical structure development
GO:0060032 IEA notochord regression
GO:0060322 IEA head development
GO:0060513 IEA prostatic bud formation
GO:0060603 IEA mammary gland duct morphogenesis
GO:0060831 IEA smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0071407 IEA cellular response to organic cyclic compound
GO:0072372 IEA primary cilium
GO:0090103 IEA cochlea morphogenesis
GO:0097542 IEA ciliary tip
GO:0098586 IDA cellular response to virus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020884 gli2b GLI-Kruppel family member GLI2b protein_coding Danio_rerio
ENSMUSG00000048402 Gli2 GLI-Kruppel family member GLI2 protein_coding Mus_musculus

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