C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: p21 protein (Cdc42/Rac)-activated kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000077264 PAK3 9606 + X:110944285-111227361 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262836 PAK3-201 111123077-111220918 protein_coding
  ENST00000360648 PAK3-202 111123077-111220918 protein_coding
  ENST00000372007 PAK3-001 111096377-111227361 protein_coding
  ENST00000372010 PAK3-002 111096360-111220931 protein_coding
  ENST00000417227 PAK3-203 111123077-111220918 protein_coding
  ENST00000425146 PAK3-204 110944285-111220918 protein_coding
  ENST00000429193 PAK3-003 111123076-111152416 protein_coding
  ENST00000446737 PAK3-205 110944285-111220918 protein_coding
  ENST00000484442 PAK3-004 111096325-111098786 processed_transcript
  ENST00000487802 PAK3-005 111142143-111152762 processed_transcript
  ENST00000518291 PAK3-007 111097387-111220447 protein_coding
  ENST00000519681 PAK3-006 111096360-111220945 protein_coding
  ENST00000620137 PAK3-206 111096147-111220945 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262836ENST00000372007ENST00000372010ENST00000425146ENST00000429193ENST00000487802ENST00000518291ENST00000620137
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262836 N/A N/A N/A 8.552±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000372007 0.098±0.00 0.131±0.00 0.014±0.00 1.592±0.00 0.411±0.00 N/A 0.031±0.00 N/A 0.092±0.00 0.131±0.03 0.011±0.00 0.174±0.17 0.037±0.01 1.029±0.07
ENST00000372010 N/A N/A N/A N/A N/A N/A N/A 0.003±0.00 N/A N/A N/A N/A N/A N/A
ENST00000425146 N/A N/A 0.030±0.00 N/A 0.221±0.00 0.192±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000429193 N/A 0.494±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000487802 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.046±0.00 N/A N/A N/A
ENST00000518291 N/A N/A 0.166±0.00 N/A N/A N/A 0.023±0.00 N/A 0.554±0.00 0.466±0.00 N/A N/A 0.200±0.00 N/A
ENST00000620137 N/A N/A N/A 5.291±0.00 0.269±0.00 N/A N/A 0.024±0.00 0.261±0.00 N/A N/A 0.103±0.00 0.151±0.12 0.593±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00079V CIL_00079V_0001 CGP X:110673856-111227361
CIL_00079U CIL_00079U_0001 CGP X:110944285-111270523

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0000187 IDA activation of MAPK activity
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IDA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005768 IEA endosome
GO:0006468 IEA protein phosphorylation
GO:0007015 IEA actin filament organization
GO:0007409 ISS axonogenesis
GO:0010975 IEA regulation of neuron projection development
GO:0016358 ISS dendrite development
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017048 IEA Rho GTPase binding
GO:0017124 IEA SH3 domain binding
GO:0030833 IDA regulation of actin filament polymerization
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0046872 IEA metal ion binding
GO:0050808 TAS synapse organization
GO:0051020 IEA GTPase binding
GO:0060997 TAS dendritic spine morphogenesis
GO:0061003 IEA positive regulation of dendritic spine morphogenesis
GO:2000573 IEA positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000031284 Pak3 p21 protein (Cdc42/Rac)-activated kinase 3 protein_coding Mus_musculus

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