C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: p21 protein (Cdc42/Rac)-activated kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031284 Pak3 10090 + X:143518591-143797796 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033640 Pak3-008 143518591-143797792 protein_coding
  ENSMUST00000112863 Pak3-001 143665745-143797792 protein_coding
  ENSMUST00000112864 Pak3-002 143665745-143797792 protein_coding
  ENSMUST00000112865 Pak3-004 143664579-143797792 protein_coding
  ENSMUST00000112868 Pak3-005 143664290-143797792 protein_coding
  ENSMUST00000126592 Pak3-003 143664373-143693384 protein_coding
  ENSMUST00000134402 Pak3-009 143518698-143765378 protein_coding
  ENSMUST00000155215 Pak3-007 143664526-143733143 protein_coding
  ENSMUST00000156449 Pak3-006 143664391-143716145 protein_coding
  ENSMUST00000172330 Pak3-201 143693286-143797796 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033640ENSMUST00000112864ENSMUST00000112865ENSMUST00000112868ENSMUST00000126592ENSMUST00000134402ENSMUST00000155215ENSMUST00000156449ENSMUST00000172330
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033640 0.086±0.00 N/A N/A 1.514±0.27 0.174±0.05 0.016±0.00 0.035±0.02 0.023±0.00 N/A N/A N/A 0.474±0.08 N/A N/A
ENSMUST00000112864 N/A N/A N/A N/A 0.124±0.00 N/A N/A N/A N/A N/A N/A 0.978±0.49 N/A 0.318±0.11
ENSMUST00000112865 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.729±0.30 N/A 0.283±0.00
ENSMUST00000112868 0.096±0.00 0.191±0.00 N/A N/A N/A N/A N/A 0.005±0.00 0.003±0.00 0.069±0.00 0.003±0.00 1.498±0.91 0.009±0.01 0.253±0.00
ENSMUST00000126592 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.147±0.00 N/A 2.815±0.00 N/A 6.005±1.14
ENSMUST00000134402 N/A N/A N/A N/A 0.197±0.00 N/A N/A N/A N/A N/A N/A N/A 0.044±0.00 5.318±0.00
ENSMUST00000155215 N/A 0.084±0.00 N/A N/A N/A N/A 0.093±0.00 0.062±0.00 N/A N/A N/A N/A 0.032±0.00 N/A
ENSMUST00000156449 N/A 0.440±0.12 N/A N/A 0.194±0.02 N/A 0.116±0.00 0.076±0.02 N/A N/A N/A N/A N/A N/A
ENSMUST00000172330 0.063±0.01 0.278±0.19 0.380±0.12 8.876±2.04 0.117±0.05 0.096±0.04 0.031±0.01 0.019±0.01 0.020±0.01 0.093±0.00 0.010±0.00 1.896±0.90 0.008±0.00 0.504±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00079V CIL_00079V_0002 CGP X:143285674-143797796
CIL_00079U CIL_00079U_0002 CGP X:143518591-143827414

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 IEA activation of MAPK activity
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 ISS MAP kinase kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005768 IEA endosome
GO:0006468 IEA protein phosphorylation
GO:0007409 IMP axonogenesis
GO:0010975 IEA regulation of neuron projection development
GO:0016358 IMP dendrite development
GO:0017048 IPI Rho GTPase binding
GO:0017124 IEA SH3 domain binding
GO:0030833 ISS regulation of actin filament polymerization
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0046872 IEA metal ion binding
GO:0051020 IEA GTPase binding
GO:0061003 IEA positive regulation of dendritic spine morphogenesis
GO:2000573 IEA positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000077264 PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 protein_coding Homo_sapiens

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