C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: actinin, alpha 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000077522 ACTN2 9606 + 1:236686454-236764631 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366578 ACTN2-001 236686508-236764631 protein_coding
  ENST00000461367 ACTN2-002 236753899-236762566 processed_transcript
  ENST00000492101 ACTN2-005 236747700-236748140 processed_transcript
  ENST00000492634 ACTN2-004 236686527-236744769 processed_transcript
  ENST00000494762 ACTN2-003 236737019-236742921 processed_transcript
  ENST00000542672 ACTN2-201 236686454-236764620 protein_coding
  ENST00000546208 ACTN2-202 236686454-236764620 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000366578ENST00000461367ENST00000492634ENST00000494762ENST00000542672ENST00000546208
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000366578 0.049±0.00 N/A 0.053±0.00 2.488±0.86 5.716±5.55 0.231±0.00 119.687±69.39 0.022±0.00 2.244±0.00 0.722±0.10 258.414±17.98 0.121±0.15 0.182±0.20 4.004±3.14
ENST00000461367 0.132±0.00 0.368±0.00 N/A 5.276±0.00 18.971±0.00 N/A 381.940±0.00 0.117±0.08 0.339±0.00 4.710±0.00 466.043±200.18 0.680±0.81 0.923±0.82 12.195±0.00
ENST00000492634 0.075±0.00 0.176±0.00 N/A N/A 4.991±4.79 0.298±0.00 350.503±0.00 0.095±0.08 0.034±0.00 1.394±0.00 436.824±0.00 0.193±0.00 0.357±0.29 5.325±2.83
ENST00000494762 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.331±0.00 N/A 11.121±0.00
ENST00000542672 N/A N/A N/A 2.617±0.00 N/A N/A N/A N/A N/A 0.533±0.00 N/A 0.026±0.02 N/A 0.701±0.00
ENST00000546208 N/A N/A N/A N/A N/A 0.077±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00097Y CIL_00097Y_0001 VISTA 1:236338883-236940914

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002576 TAS platelet degranulation
GO:0005178 TAS integrin binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005829 TAS cytosol
GO:0005856 NAS cytoskeleton
GO:0005884 TAS actin filament
GO:0005925 IMP focal adhesion
GO:0006936 IEA muscle contraction
GO:0007155 TAS cell adhesion
GO:0007268 TAS synaptic transmission
GO:0007596 TAS blood coagulation
GO:0008092 IDA cytoskeletal protein binding
GO:0008307 TAS structural constituent of muscle
GO:0030017 IEA sarcomere
GO:0030018 IDA Z disc
GO:0030035 IDA microspike assembly
GO:0030049 TAS muscle filament sliding
GO:0030168 TAS platelet activation
GO:0030175 IDA filopodium
GO:0030274 IEA LIM domain binding
GO:0030374 IEA ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 IEA thyroid hormone receptor coactivator activity
GO:0030864 IEA cortical actin cytoskeleton
GO:0031093 TAS platelet alpha granule lumen
GO:0031143 TAS pseudopodium
GO:0031432 IPI titin binding
GO:0042391 IMP regulation of membrane potential
GO:0042802 IPI identical protein binding
GO:0042981 NAS regulation of apoptotic process
GO:0043197 TAS dendritic spine
GO:0043267 IMP negative regulation of potassium ion transport
GO:0043268 IDA positive regulation of potassium ion transport
GO:0044325 IPI ion channel binding
GO:0046983 IDA protein dimerization activity
GO:0048041 IMP focal adhesion assembly
GO:0051015 IEA actin filament binding
GO:0051289 IDA protein homotetramerization
GO:0051373 IDA FATZ binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070080 IPI titin Z domain binding
GO:1901017 IMP negative regulation of potassium ion transmembrane transporter activity
GO:1901018 IDA positive regulation of potassium ion transmembrane transporter activity
GO:2000009 IMP negative regulation of protein localization to cell surface
GO:2000273 IEA positive regulation of receptor activity
GO:2001141 IEA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071090 actn2 actinin, alpha 2 protein_coding Danio_rerio
ENSMUSG00000052374 Actn2 actinin alpha 2 protein_coding Mus_musculus

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