C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glycogen synthase kinase 3 beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000082701 GSK3B 9606 - 3:119821323-120094417 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264235 GSK3B-001 119821323-120094417 protein_coding
  ENST00000316626 GSK3B-002 119826686-120093666 protein_coding
  ENST00000473886 GSK3B-004 119826701-119876508 processed_transcript
  ENST00000474830 GSK3B-003 119826693-119843609 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264235ENST00000316626ENST00000473886
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264235 6.787±0.00 3.767±0.00 2.229±0.00 9.058±1.71 4.789±1.53 3.502±0.64 3.586±2.76 3.392±0.00 2.275±1.04 4.021±1.13 5.050±0.00 3.482±0.84 4.002±0.09 4.235±1.28
ENST00000316626 4.897±0.00 N/A 3.309±0.00 13.161±0.00 8.528±0.00 3.743±1.29 6.603±0.00 3.600±0.00 3.771±0.30 9.549±1.89 4.184±0.00 6.389±3.02 3.723±0.24 11.014±0.45
ENST00000473886 N/A N/A 15.097±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005BP CIL_0005BP_0002 CGP 3:119780484-120094417
CIL_0002U6 CIL_0002U6_0002 CGP 3:119821323-120285094

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000320 IEA re-entry into mitotic cell cycle
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001837 IMP epithelial to mesenchymal transition
GO:0001954 IMP positive regulation of cell-matrix adhesion
GO:0002039 IDA p53 binding
GO:0004672 IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005977 IDA glycogen metabolic process
GO:0006349 IEA regulation of gene expression by genetic imprinting
GO:0006468 IDA:IEA protein phosphorylation
GO:0006611 IEA protein export from nucleus
GO:0006983 IDA ER overload response
GO:0007163 IEA establishment or maintenance of cell polarity
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007409 IEA axonogenesis
GO:0007411 TAS axon guidance
GO:0007520 IEA myoblast fusion
GO:0007623 ISS circadian rhythm
GO:0008013 IPI beta-catenin binding
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009887 IEA organ morphogenesis
GO:0010226 IEA response to lithium ion
GO:0010614 IEA negative regulation of cardiac muscle hypertrophy
GO:0010800 IEA positive regulation of peptidyl-threonine phosphorylation
GO:0010975 IEA regulation of neuron projection development
GO:0010977 IEA negative regulation of neuron projection development
GO:0014043 IEA negative regulation of neuron maturation
GO:0014902 IEA myotube differentiation
GO:0016020 IEA membrane
GO:0016055 IEA Wnt signaling pathway
GO:0016301 IDA kinase activity
GO:0016310 IEA phosphorylation
GO:0016477 IEA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0021766 IMP hippocampus development
GO:0030010 IEA establishment of cell polarity
GO:0030426 IEA growth cone
GO:0030529 IEA ribonucleoprotein complex
GO:0030877 IDA beta-catenin destruction complex
GO:0031333 IMP negative regulation of protein complex assembly
GO:0031334 IDA positive regulation of protein complex assembly
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032091 IDA negative regulation of protein binding
GO:0032092 ISS positive regulation of protein binding
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0032886 IMP regulation of microtubule-based process
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034236 IPI protein kinase A catalytic subunit binding
GO:0035255 IEA ionotropic glutamate receptor binding
GO:0035372 IEA protein localization to microtubule
GO:0035556 IDA intracellular signal transduction
GO:0036016 ISS cellular response to interleukin-3
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042493 IEA response to drug
GO:0043025 IEA neuronal cell body
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043197 IEA dendritic spine
GO:0043198 IEA dendritic shaft
GO:0043227 IEA membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043407 IEA negative regulation of MAP kinase activity
GO:0044027 IEA hypermethylation of CpG island
GO:0044297 IEA cell body
GO:0044337 IEA canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045121 IEA membrane raft
GO:0045444 IEA fat cell differentiation
GO:0045719 TAS negative regulation of glycogen biosynthetic process
GO:0045732 IC positive regulation of protein catabolic process
GO:0045773 IEA positive regulation of axon extension
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046827 IDA positive regulation of protein export from nucleus
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048156 IEA tau protein binding
GO:0048168 IEA regulation of neuronal synaptic plasticity
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050321 IDA tau-protein kinase activity
GO:0050774 IEA negative regulation of dendrite morphogenesis
GO:0051059 IPI NF-kappaB binding
GO:0051534 IMP negative regulation of NFAT protein import into nucleus
GO:0060070 IDA canonical Wnt signaling pathway
GO:0071109 IMP superior temporal gyrus development
GO:0071260 IEA cellular response to mechanical stimulus
GO:0090090 TAS negative regulation of canonical Wnt signaling pathway
GO:0097192 ISS extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 ISS positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000077 TAS negative regulation of type B pancreatic cell development
GO:2000466 TAS negative regulation of glycogen (starch) synthase activity
GO:2000738 IEA positive regulation of stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017803 gsk3b glycogen synthase kinase 3 beta protein_coding Danio_rerio
ENSDARG00000052468 GSK3B (2 of 2) glycogen synthase kinase 3 beta protein_coding Danio_rerio
ENSMUSG00000022812 Gsk3b glycogen synthase kinase 3 beta protein_coding Mus_musculus

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