C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000083520 DIS3 9606 - 13:72752169-72782096 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000377767 DIS3-001 72752169-72781933 protein_coding
  ENST00000377780 DIS3-002 72757443-72781925 protein_coding
  ENST00000475871 DIS3-004 72780846-72782094 processed_transcript
  ENST00000490646 DIS3-003 72759675-72781854 nonsense_mediated_decay
  ENST00000545453 DIS3-201 72759044-72782096 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000377767ENST00000377780ENST00000490646ENST00000545453
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000377767 0.992±0.00 0.890±0.00 0.709±0.00 0.699±0.23 1.112±0.16 0.842±0.23 0.428±0.11 0.943±0.41 0.792±0.00 0.652±0.01 0.282±0.00 1.699±0.73 0.726±0.18 1.402±0.00
ENST00000377780 1.572±0.00 2.575±0.00 N/A 1.517±0.34 1.751±0.00 1.098±0.00 1.004±0.49 2.088±0.90 1.845±0.69 2.719±0.40 0.586±0.11 3.159±1.38 2.019±1.14 5.427±1.42
ENST00000490646 N/A N/A 1.722±0.00 1.721±0.00 N/A 2.357±1.09 1.111±0.00 N/A 2.231±0.00 2.117±0.00 0.472±0.00 7.250±0.00 4.013±0.00 9.854±0.00
ENST00000545453 2.642±0.00 2.584±0.00 N/A 1.670±0.00 2.639±0.00 1.399±0.00 1.880±0.00 2.173±0.00 N/A 3.373±0.00 2.217±0.00 2.878±0.00 1.196±0.02 8.534±2.61

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00095B CIL_00095B_0001 VISTA 13:72193463-72794242
CIL_000955 CIL_000955_0001 VISTA 13:72204429-72805745
CIL_0009CH CIL_0009CH_0001 VISTA 13:72207309-72809616
CIL_0009CG CIL_0009CG_0001 VISTA 13:72212874-72814683
CIL_000956 CIL_000956_0001 VISTA 13:72274916-72875890
CIL_0009CJ CIL_0009CJ_0001 VISTA 13:72350262-72951768
CIL_0004PC CIL_0004PC_0002 CGP 13:72708357-72756198
CIL_0005KC CIL_0005KC_0002 CGP 13:72727749-72782096
CIL_0002NH CIL_0002NH_0001 CGP 13:72752169-73016461

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000175 IMP 3'-5'-exoribonuclease activity
GO:0000176 IDA nuclear exosome (RNase complex)
GO:0000178 TAS exosome (RNase complex)
GO:0000288 TAS nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0003723 IEA RNA binding
GO:0004519 IMP endonuclease activity
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006364 TAS rRNA processing
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016075 IMP rRNA catabolic process
GO:0043547 IDA positive regulation of GTPase activity
GO:0043928 TAS exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071034 IMP CUT catabolic process
GO:0090305 IMP nucleic acid phosphodiester bond hydrolysis
GO:0090503 IMP RNA phosphodiester bond hydrolysis, exonucleolytic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060559 dis3 DIS3 mitotic control homolog (S. cerevisiae) protein_coding Danio_rerio
ENSMUSG00000033166 Dis3 DIS3 mitotic control homolog (S. cerevisiae) protein_coding Mus_musculus

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