C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000377767 DIS3-001 ENSG00000083520 9606 - 13:72752169-72781933 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000377767
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000377767 0.992±0.00 0.890±0.00 0.709±0.00 0.699±0.23 1.112±0.16 0.842±0.23 0.428±0.11 0.943±0.41 0.792±0.00 0.652±0.01 0.282±0.00 1.699±0.73 0.726±0.18 1.402±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00095B CIL_00095B_0001 VISTA 13:72193463-72794242
CIL_000955 CIL_000955_0001 VISTA 13:72204429-72805745
CIL_0009CH CIL_0009CH_0001 VISTA 13:72207309-72809616
CIL_0009CG CIL_0009CG_0001 VISTA 13:72212874-72814683
CIL_000956 CIL_000956_0001 VISTA 13:72274916-72875890
CIL_0009CJ CIL_0009CJ_0001 VISTA 13:72350262-72951768
CIL_0004PC CIL_0004PC_0002 CGP 13:72708357-72756198
CIL_0005KC CIL_0005KC_0002 CGP 13:72727749-72782096
CIL_0002NH CIL_0002NH_0001 CGP 13:72752169-73016461

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000175 IMP 3'-5'-exoribonuclease activity
GO:0000176 IDA nuclear exosome (RNase complex)
GO:0000178 TAS exosome (RNase complex)
GO:0000288 TAS nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0003723 IEA RNA binding
GO:0004519 IMP endonuclease activity
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006364 TAS rRNA processing
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016075 IMP rRNA catabolic process
GO:0043547 IDA positive regulation of GTPase activity
GO:0043928 TAS exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071034 IMP CUT catabolic process
GO:0090305 IMP nucleic acid phosphodiester bond hydrolysis
GO:0090503 IMP RNA phosphodiester bond hydrolysis, exonucleolytic

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000042471 Dis3-201 protein_coding Mus_musculus 0 3267
ENSMUST00000022650 Pibf1-201 protein_coding Mus_musculus 0 265
ENSMUST00000096575 Map3k2-201 protein_coding Mus_musculus 0.00001 58

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