C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thrombopoietin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000090534 THPO 9606 - 3:184371935-184378144 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000204615 THPO-001 184371935-184378144 protein_coding
  ENST00000421442 THPO-003 184372327-184376259 protein_coding
  ENST00000445696 THPO-002 184372269-184378140 protein_coding
  ENST00000477594 THPO-004 184372898-184373437 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000204615ENST00000421442ENST00000445696
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000204615 N/A N/A 0.152±0.00 N/A 0.225±0.00 0.248±0.00 N/A 0.218±0.00 1.557±0.00 N/A N/A 0.159±0.00 N/A N/A
ENST00000421442 0.411±0.00 0.600±0.00 N/A 0.515±0.37 0.568±0.00 N/A 0.141±0.00 1.461±0.00 4.893±0.00 0.206±0.00 N/A 0.523±0.31 0.322±0.08 1.247±0.00
ENST00000445696 0.163±0.00 0.112±0.00 N/A 0.509±0.00 0.228±0.00 N/A N/A 0.498±0.00 5.605±0.00 0.141±0.00 0.070±0.00 0.299±0.15 0.088±0.00 0.597±0.33

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005G3 CIL_0005G3_0001 CGP 3:184135038-184684758
CIL_00056Y CIL_00056Y_0001 CGP 3:184361718-184378144
CIL_00056V CIL_00056V_0001 CGP 3:184371935-184390736

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0005125 IEA cytokine activity
GO:0005179 IEA hormone activity
GO:0005576 IEA extracellular region
GO:0005615 IEA extracellular space
GO:0007275 TAS multicellular organismal development
GO:0007596 TAS blood coagulation
GO:0008083 TAS growth factor activity
GO:0008283 IEA cell proliferation
GO:0030099 IEA myeloid cell differentiation
GO:0030168 TAS platelet activation
GO:0038163 ISS thrombopoietin-mediated signaling pathway
GO:0045654 ISS positive regulation of megakaryocyte differentiation
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000022847 Thpo thrombopoietin protein_coding Mus_musculus

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