C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TYRO3 protein tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000092445 TYRO3 9606 + 15:41557675-41583586 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263798 TYRO3-001 41559034-41583586 protein_coding
  ENST00000559066 TYRO3-002 41557675-41578805 protein_coding
  ENST00000559815 TYRO3-006 41567379-41570339 nonsense_mediated_decay
  ENST00000559851 TYRO3-008 41571103-41573467 nonsense_mediated_decay
  ENST00000560162 TYRO3-007 41570938-41573377 retained_intron
  ENST00000560227 TYRO3-005 41564784-41568265 retained_intron
  ENST00000560992 TYRO3-003 41559227-41562355 retained_intron
  ENST00000568343 TYRO3-010 41570677-41577973 protein_coding
  ENST00000568490 TYRO3-011 41577335-41579338 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263798ENST00000559066ENST00000559851ENST00000560992ENST00000568343ENST00000568490
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263798 2.857±0.00 N/A 0.099±0.00 4.110±3.04 1.963±1.83 0.142±0.08 0.154±0.10 0.767±0.74 0.219±0.08 0.281±0.13 0.105±0.00 2.066±1.47 0.359±0.05 2.003±0.00
ENST00000559066 N/A N/A 0.378±0.00 6.659±0.83 5.152±0.00 0.343±0.17 0.455±0.00 2.119±2.05 0.466±0.00 0.696±0.30 0.105±0.03 9.046±11.44 3.455±1.78 5.149±0.52
ENST00000559851 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.396±0.00 N/A
ENST00000560992 N/A N/A N/A N/A N/A N/A N/A N/A 0.799±0.00 N/A N/A N/A N/A N/A
ENST00000568343 N/A N/A 1.852±0.00 21.706±0.00 1.513±0.00 1.734±0.52 0.836±0.00 4.607±4.35 1.857±0.00 N/A 1.687±0.00 N/A N/A N/A
ENST00000568490 4.212±0.00 0.834±0.00 0.716±0.00 14.811±0.34 6.365±5.08 1.171±0.68 0.478±0.05 4.356±4.12 0.451±0.00 2.616±0.00 0.271±0.00 14.958±9.84 4.185±1.58 15.375±2.48

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005F5 CIL_0005F5_0001 CGP 15:41517176-41583586
CIL_0005F6 CIL_0005F6_0001 CGP 15:41557675-41773081

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001779 IEA natural killer cell differentiation
GO:0004672 IEA protein kinase activity
GO:0004713 IEA:IDA protein tyrosine kinase activity
GO:0004714 NAS transmembrane receptor protein tyrosine kinase activity
GO:0004716 NAS receptor signaling protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005635 ISS nuclear envelope
GO:0005789 ISS endoplasmic reticulum membrane
GO:0005887 NAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007155 NAS cell adhesion
GO:0007165 NAS signal transduction
GO:0007283 ISS spermatogenesis
GO:0014065 NAS phosphatidylinositol 3-kinase signaling
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0021885 ISS forebrain cell migration
GO:0023014 NAS signal transduction by phosphorylation
GO:0030168 ISS platelet activation
GO:0032940 ISS secretion by cell
GO:0034122 ISS negative regulation of toll-like receptor signaling pathway
GO:0034446 ISS substrate adhesion-dependent cell spreading
GO:0042698 ISS ovulation cycle
GO:0043277 ISS apoptotic cell clearance
GO:0043491 ISS protein kinase B signaling
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043548 IPI phosphatidylinositol 3-kinase binding
GO:0045824 ISS negative regulation of innate immune response
GO:0046777 IDA protein autophosphorylation
GO:0046982 IEA protein heterodimerization activity
GO:0050728 ISS negative regulation of inflammatory response
GO:0051250 IEA negative regulation of lymphocyte activation
GO:0060068 IEA vagina development
GO:0070050 ISS neuron cellular homeostasis
GO:0070527 ISS platelet aggregation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005356 tyro3 TYRO3 protein tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000027298 Tyro3 TYRO3 protein tyrosine kinase 3 protein_coding Mus_musculus

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