C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TYRO3 protein tyrosine kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027298 Tyro3 10090 + 2:119797733-119818104 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028763 Tyro3-002 119799514-119818104 protein_coding
  ENSMUST00000110783 Tyro3-001 119797733-119818104 protein_coding
  ENSMUST00000130456 Tyro3-007 119803087-119807990 retained_intron
  ENSMUST00000135726 Tyro3-006 119801116-119803293 processed_transcript
  ENSMUST00000137135 Tyro3-008 119810846-119812391 retained_intron
  ENSMUST00000147636 Tyro3-004 119799239-119805650 processed_transcript
  ENSMUST00000147761 Tyro3-003 119809208-119818091 retained_intron
  ENSMUST00000148343 Tyro3-005 119799327-119803335 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028763ENSMUST00000110783ENSMUST00000147636ENSMUST00000147761ENSMUST00000148343
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028763 1.765±1.66 1.450±0.36 16.216±3.32 10.663±1.52 1.144±0.19 4.173±1.00 0.209±0.07 0.517±0.34 0.143±0.15 4.531±2.45 0.112±0.04 7.753±3.51 2.969±1.37 7.681±3.62
ENSMUST00000110783 N/A 0.757±0.35 N/A N/A N/A 1.827±0.14 N/A N/A 0.087±0.02 N/A N/A 5.063±2.60 0.881±0.00 0.465±0.00
ENSMUST00000147636 N/A N/A N/A N/A 2.185±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000147761 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.058±0.02 N/A N/A 0.474±0.00
ENSMUST00000148343 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.223±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005F5 CIL_0005F5_0002 CGP 2:119763304-119818104
CIL_0005F6 CIL_0005F6_0002 CGP 2:119797733-119969581

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001779 IGI natural killer cell differentiation
GO:0004713 ISS protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005635 ISS nuclear envelope
GO:0005789 ISS endoplasmic reticulum membrane
GO:0005886 IEA plasma membrane
GO:0007283 IGI spermatogenesis
GO:0016021 IEA integral component of membrane
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0021885 IGI forebrain cell migration
GO:0030168 IMP platelet activation
GO:0032940 IMP secretion by cell
GO:0034122 IGI negative regulation of toll-like receptor signaling pathway
GO:0034446 IMP substrate adhesion-dependent cell spreading
GO:0042698 IGI ovulation cycle
GO:0043277 IGI apoptotic cell clearance
GO:0043491 IGI protein kinase B signaling
GO:0043524 IGI negative regulation of neuron apoptotic process
GO:0043548 ISS phosphatidylinositol 3-kinase binding
GO:0045824 IGI negative regulation of innate immune response
GO:0046777 ISS protein autophosphorylation
GO:0046982 IPI protein heterodimerization activity
GO:0050728 IGI negative regulation of inflammatory response
GO:0051250 IGI negative regulation of lymphocyte activation
GO:0060068 IGI vagina development
GO:0070050 IMP neuron cellular homeostasis
GO:0070527 IMP platelet aggregation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005356 tyro3 TYRO3 protein tyrosine kinase protein_coding Danio_rerio
ENSG00000092445 TYRO3 TYRO3 protein tyrosine kinase protein_coding Homo_sapiens

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