C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mutS homolog 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000095002 MSH2 9606 + 2:47402969-47562311 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000233146 MSH2-001 47402969-47483228 protein_coding
  ENST00000406134 MSH2-002 47403130-47513234 protein_coding
  ENST00000454849 MSH2-003 47403067-47410346 protein_coding
  ENST00000461394 MSH2-005 47480797-47562311 processed_transcript
  ENST00000467323 MSH2-006 47555859-47562311 processed_transcript
  ENST00000543555 MSH2-201 47403067-47483227 protein_coding
  ENST00000610696 MSH2-202 47403152-47483023 protein_coding
  ENST00000613514 MSH2-203 47403152-47483023 protein_coding
  ENST00000617333 MSH2-204 47403152-47483023 protein_coding
  ENST00000617938 MSH2-205 47403152-47483023 protein_coding
  ENST00000621359 MSH2-206 47403152-47483023 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000233146ENST00000406134ENST00000454849ENST00000543555ENST00000617938
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000233146 3.103±0.00 0.991±0.00 N/A 3.190±0.83 2.635±0.00 0.611±0.27 0.854±0.15 5.640±0.00 0.420±0.00 0.698±0.08 0.259±0.00 5.858±4.39 3.563±0.43 8.419±1.66
ENST00000406134 N/A N/A N/A 0.697±0.02 N/A N/A N/A N/A N/A N/A N/A 1.061±0.00 N/A N/A
ENST00000454849 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.380±0.00 N/A N/A N/A
ENST00000543555 N/A 1.717±0.00 N/A N/A 0.560±0.00 N/A 1.160±0.00 0.446±0.00 0.489±0.13 0.285±0.00 0.504±0.00 2.776±2.29 4.462±0.00 1.703±0.62
ENST00000617938 N/A 1.115±0.00 0.730±0.00 2.138±0.00 4.299±0.00 1.694±0.58 0.837±0.00 N/A 1.544±0.00 1.712±1.27 0.534±0.35 5.095±0.00 N/A 1.357±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006KU CIL_0006KU_0001 CGP 2:47345158-47562311
CIL_0006KS CIL_0006KS_0001 CGP 2:47402969-47570939

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000228 IBA nuclear chromosome
GO:0000287 IDA magnesium ion binding
GO:0000400 IDA four-way junction DNA binding
GO:0000403 IBA Y-form DNA binding
GO:0000404 IBA heteroduplex DNA loop binding
GO:0000406 IBA double-strand/single-strand DNA junction binding
GO:0000710 IBA meiotic mismatch repair
GO:0001701 IEA in utero embryonic development
GO:0002204 IEA somatic recombination of immunoglobulin genes involved in immune response
GO:0003677 IDA DNA binding
GO:0003684 IEA damaged DNA binding
GO:0003690 IDA double-stranded DNA binding
GO:0003697 IDA single-stranded DNA binding
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005634 IEA nucleus
GO:0006119 IEA oxidative phosphorylation
GO:0006200 IBA ATP catabolic process
GO:0006281 IDA DNA repair
GO:0006298 IDA:IEA mismatch repair
GO:0006301 IDA postreplication repair
GO:0006302 IBA double-strand break repair
GO:0006311 IBA meiotic gene conversion
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007050 IEA cell cycle arrest
GO:0007281 IEA germ cell development
GO:0008022 IPI protein C-terminus binding
GO:0008094 IBA DNA-dependent ATPase activity
GO:0008340 IEA determination of adult lifespan
GO:0008584 ISS male gonad development
GO:0008630 IEA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165 ISS response to X-ray
GO:0010224 ISS response to UV-B
GO:0016020 IDA membrane
GO:0016446 IBA somatic hypermutation of immunoglobulin genes
GO:0016447 ISS somatic recombination of immunoglobulin gene segments
GO:0016887 IDA ATPase activity
GO:0019237 IEA centromeric DNA binding
GO:0019724 ISS B cell mediated immunity
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030183 ISS B cell differentiation
GO:0030983 IDA:IEA mismatched DNA binding
GO:0031573 IBA intra-S DNA damage checkpoint
GO:0032137 IMP guanine/thymine mispair binding
GO:0032139 IDA dinucleotide insertion or deletion binding
GO:0032142 IDA single guanine insertion binding
GO:0032143 IDA single thymine insertion binding
GO:0032181 IDA dinucleotide repeat insertion binding
GO:0032301 IDA:IEA MutSalpha complex
GO:0032302 IDA:IEA MutSbeta complex
GO:0032357 IDA oxidized purine DNA binding
GO:0032405 IDA MutLalpha complex binding
GO:0042771 IBA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 IDA protein homodimerization activity
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043531 IDA ADP binding
GO:0043570 IMP maintenance of DNA repeat elements
GO:0045128 IBA negative regulation of reciprocal meiotic recombination
GO:0045190 ISS isotype switching
GO:0045910 ISS negative regulation of DNA recombination
GO:0051096 IDA positive regulation of helicase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018022 msh2 mutS homolog 2 (E. coli) protein_coding Danio_rerio
ENSMUSG00000024151 Msh2 mutS homolog 2 (E. coli) protein_coding Mus_musculus

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