C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000095015 MAP3K1 9606 + 5:56815574-56896152 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000399503 MAP3K1-001 56815574-56896152 protein_coding
  ENST00000469188 MAP3K1-002 56885953-56896152 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000399503ENST00000469188
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000399503 2.626±0.00 5.418±0.00 2.902±0.00 0.964±0.06 3.043±0.93 2.069±0.71 1.208±0.19 3.242±0.00 2.395±1.63 3.416±0.40 0.580±0.32 2.346±1.34 3.280±1.19 4.581±0.86
ENST00000469188 N/A 1.588±0.00 N/A N/A N/A N/A N/A 1.881±0.00 N/A 0.548±0.00 N/A 1.260±0.00 N/A 0.935±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008EO CIL_0008EO_0001 VISTA 5:56300346-56903242
CIL_00089D CIL_00089D_0001 VISTA 5:56348801-56951831

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0003382 IEA epithelial cell morphogenesis
GO:0004672 IDA:IEA protein kinase activity
GO:0004709 NAS MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006468 NAS:IEA protein phosphorylation
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007254 IEA JNK cascade
GO:0007257 IEA activation of JUN kinase activity
GO:0008270 IEA zinc ion binding
GO:0008545 IEA JUN kinase kinase activity
GO:0008637 IEA apoptotic mitochondrial changes
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IPI protein kinase binding
GO:0030334 IEA regulation of cell migration
GO:0030838 IEA positive regulation of actin filament polymerization
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042060 IEA wound healing
GO:0043010 IEA camera-type eye development
GO:0045087 TAS innate immune response
GO:0061029 IEA eyelid development in camera-type eye
GO:0071260 IEP cellular response to mechanical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000088180 map3k1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSMUSG00000021754 Map3k1 mitogen-activated protein kinase kinase kinase 1 protein_coding Mus_musculus

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