C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021754 Map3k1 10090 - 13:111746428-111808993 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000109267 Map3k1-001 111746428-111808993 protein_coding
  ENSMUST00000130594 Map3k1-004 111753568-111754704 retained_intron
  ENSMUST00000133364 Map3k1-003 111767609-111768553 processed_transcript
  ENSMUST00000145055 Map3k1-002 111767984-111808315 protein_coding
  ENSMUST00000175936 Map3k1-005 111748793-111751373 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000109267
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000109267 2.371±0.93 4.573±0.81 1.052±0.27 0.922±0.19 7.176±4.60 3.831±0.71 1.415±0.68 2.793±1.55 0.680±0.40 4.220±1.25 0.395±0.02 5.764±1.15 1.603±0.39 0.670±0.54

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089D CIL_00089D_0002 VISTA 13:111652900-112255571
CIL_0008EO CIL_0008EO_0002 VISTA 13:111689320-112293362

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003382 IMP epithelial cell morphogenesis
GO:0004672 ISO protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0006468 IEA:ISO protein phosphorylation
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0007254 IDA JNK cascade
GO:0007257 IDA activation of JUN kinase activity
GO:0008270 IEA zinc ion binding
GO:0008545 IDA JUN kinase kinase activity
GO:0008637 IMP apoptotic mitochondrial changes
GO:0019901 IEA protein kinase binding
GO:0030334 IMP regulation of cell migration
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0042060 IMP wound healing
GO:0043010 IMP camera-type eye development
GO:0061029 IMP eyelid development in camera-type eye
GO:0071260 IEA cellular response to mechanical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000088180 map3k1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSG00000095015 MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase protein_coding Homo_sapiens

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